Browsing Pharmacy Research by Author "n 94093822"
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Naked Poly(amidoamine) Dendrimer Nanoparticles Exhibit Intrinsic Embryotoxicity During the Early Stages of Normal Development.
Kheraldine, Hadeel; Gupta, Ishita; Alhussain, Hashim; Jabeen, Ayesha; Akhtar, Saghir; Al Moustafa, Ala-Eddin; Rachid, Ousama... more authors ... less authors ( American Science Publishers ASP , 2020 , Article)To investigate the impact of poly(amidoamine) dendrimers (PAMAMs) in the embryo, we explored the outcome of different generations (G₄ and G) on the early stages of embryogenesis using the chicken embryo as a model. We also ... -
Substantial cell apoptosis provoked by naked PAMAM dendrimers in HER2-positive human breast cancer via JNK and ERK1/ERK2 signalling pathways
Hadeel, Kheraldine; Gupta, Ishita; Alhussain, Hashim; Jabeen, Aayesha; Cyprian, Farhan S.; Akhtar, Saghir; Al Moustafa, Ala-Eddin; Rachid, Ousama... more authors ... less authors ( Elsevier , 2021 , Article)HER2-positive breast cancer is one of its most challenging subtypes, forming around 15–25% of the total cases. It is characterized by aggressive behavior and treatment resistance. On the other hand, poly (amidoamine) (PAMAM) ...