Browsing Pharmacy Research by Title
Now showing items 187-206 of 1183
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Circulating exosomal immuno-oncological checkpoints and cytokines are potential biomarkers to monitor tumor response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patients
( Frontiers Media S.A. , 2023 , Article)Immune checkpoint inhibitors (ICIs) including anti-PD-1 and anti-PD-L1 antibodies, have significantly changed the treatment outcomes of NSCLC patients with better overall survival. However, 15-40% of the patients still ... -
Circulating microparticles as biomarkers of stroke: A focus on the value of endothelial- and platelet-derived microparticles.
( Wiley , 2019 , Article)Stroke is one of the leading causes of mortality and disability worldwide. Numerous pathophysiological mechanisms involving blood vessels, coagulation and inflammation contribute to the vascular occlusion. Perturbations ... -
Cisplatin based therapy: The role of the mitogen activated protein kinase signaling pathway
( BioMed Central Ltd. , 2018 , Article Review)Cisplatin is a widely used chemotherapeutic agent for treatment of various cancers. However, treatment with cisplatin is associated with drug resistance and several adverse side effects such as nephrotoxicity, reduced ... -
Cisplatin-induced ototoxicity: A novel approach to an ancient problem
( Lippincott, Williams & Wilkins , 2023 , Article)With the scarcity of pharmacological otoprotective agents against cisplatin-induced ototoxicity (CIO), researchers find themselves compelled to look at and navigate all possible strategies to identify ways to prevent CIO. ... -
Clinical and Economic Analysis of Morphine Versus Fentanyl in Managing Ventilated Neonates With Respiratory Distress Syndrome in the Intensive Care Setting
( Excerpta Medica Inc. , 2019 , Article)Purpose: Morphine and fentanyl opioids are common analgesic agents for consideration in the neonatal intensive care unit (NICU) for neonates with respiratory distress syndrome (RDS) and undergoing mechanical ventilation ... -
Clinical and Economic Evaluation of the Impact of Midazolam on Morphine Therapy for Pain Relief in Critically Ill Ventilated Infants with Respiratory Distress Syndrome
( Springer , 2021 , Article)Background: The impact of midazolam on the overall performance of morphine therapy for pain in ventilated neonates with respiratory distress syndrome (RDS) has never been investigated. Objective: This study is a clinical ... -
Clinical and humanistic outcomes of community pharmacy‐based healthcare interventions regarding medication use in older adults: A systematic review and meta‐analysis
( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)This review and meta‐analysis aimed to determine the clinical and humanistic outcomes of community pharmacy‐based interventions on medication‐related problems of older adults at the primary care level. We identified ... -
Clinical and Pharmacokinetic Outcomes of Peak–Trough-Based Versus Trough-Based Vancomycin Therapeutic Drug Monitoring Approaches: A Pragmatic Randomized Controlled Trial
( Springer-Verlag France , 2019 , Article)Background Vancomycin therapeutic drug monitoring (TDM) is based on achieving 24-h area under the concentration–time curve to minimum inhibitory concentration cure breakpoints (AUC24/MIC). Approaches to vancomycin TDM ... -
Clinical benefits and costs of an outpatient parenteral antimicrobial therapy service
( Elsevier , 2021 , Article)BackgroundThe enrolment of patients to an outpatient parenteral antimicrobial therapy (OPAT) service can be a means of mitigating financial burdens related to the provision of care and optimisation of hospital bed management. ... -
Clinical outcomes of high-intensity doses of atorvastatin in patients with acute coronary syndrome: A retrospective cohort study using real-world data
( Blackwell Publishing Ltd , 2021 , Article)Aims: To compare the effectiveness and safety of 2 high-intensity atorvastatin doses (40 mg vs 80 mg) among acute coronary syndrome (ACS) patients. Methods: This retrospective observational cohort study using real-world ... -
Clinical pharmacists’ interventions for preventing adverse events in critically ill neonates in Qatar: an economic impact analysis
( Springer Nature , 2024 , Article)Objective: This study aimed to assess the overall economic impact of clinical pharmacist interventions in the neonatal ICU (NICU) in Qatar. Methods: A retrospective review of neonates’ records was performed over a 3-month ... -
Clinical pharmacokinetic drug interactions associated with artemisinin derivatives and HIV-antivirals
( Springer International Publishing , 2014 , Article Review)Management of HIV and malaria co-infection is challenging due to potential drug-drug interactions between antimalarial and HIV-antiviral drugs. Little is known of the clinical significance of these drug interactions, and ... -
Clinical Pharmacokinetics and Drug Interactions of Doravirine
( Springer-Verlag France , 2018 , Article Review)Doravirine is a new HIV-1 non-nucleoside reverse transcriptase inhibitor that has demonstrated a good efficacy and safety profile in clinical trials. It has a therapeutic profile that makes it an attractive option for ... -
Clinical pharmacokinetics: perceptions of hospital pharmacists in Qatar about how it was taught and how it is applied
( Kluwer Academic Publishers , 2015 , Article)Background The application of clinical pharmacokinetics (PK) is essential when providing pharmaceutical care. Appropriate application of PK monitoring results in improved patient outcomes including decreased mortality, ... -
Clinical pharmacy considerations in special population: Pregnancy and lactation
( Elsevier , 2019 , Book chapter)The physiological changes that occur during pregnancy and lactation may affect pharmacokinetics and pharmacodynamics of drugs. Hence, administration of medications during pregnancy and lactation may require adjustments in ... -
Clinical pharmacy service innovation in an obstetrics and gynecology setting: A case study from Qatar
( Elsevier , 2021 , Book chapter)Clinical pharmacy services have evolved rapidly and been developed largely to cover a wide range of patient care settings and therapeutic areas. However, clinical pharmacists' services in obstetrics and gynecology (OB/GYNE) ... -
Clinical usefulness of prediction tools to identify adult hospitalized patients at risk of drug-related problems: A systematic review of clinical prediction models and risk assessment tools
( Wiley , 2021 , Article Review)Aims: This study aimed to review systematically all available prediction tools identifying adult hospitalized patients at risk of drug-related problems, and to synthesize the evidence on performance and clinical usefulness. ... -
Cognitive load theory: Implications for assessment in pharmacy education
( Elsevier , 2021 , Other)The concept of mental workload is well studied from a learner's perspective but has yet to be better understood from the perspective of an assessor. Mental workload is largely associated with cognitive load theory, which ... -
Collaborative care model for diabetes in primary care settings in Qatar: a qualitative exploration among healthcare professionals and patients who experienced the service
( BioMed Central Ltd , 2021 , Article)Background: Diabetes mellitus is highly prevalent and associated with huge economic burden globally. The conventional care and management of diabetes mellitus is highly fragmented and complex, warranting the need for a ... -
Colorectal Cancer: A Review of Carcinogenesis, Global Epidemiology, Current Challenges, Risk Factors, Preventive and Treatment Strategies
( MDPI , 2022 , Article Review)Colorectal cancer (CRC) is the second most deadly cancer. Global incidence and mortality are likely to be increased in the coming decades. Although the deaths associated with CRC are very high in high-income countries, the ...