Browsing Pharmacy Research by Subject "Autophagy"

Now showing items 1-6 of 6

    • AMP-activated protein kinase as a drug target in chronic kidney disease 

      Allouch S.; Munusamy S. ( Bentham Science Publishers B.V. , 2018 , Article Review)
      Background: Chronic kidney disease (CKD) is a condition increasingly affecting millions of individuals worldwide and is ranked as the ninth leading cause of death in the United States. AMP-activated protein kinase (AMPK) ...

    • AMPK Activation Attenuates Albumin-induced Alterations in Renal Tubular Cells In Vitro 

      Allouch, Soumaya; Munusamy, Shankar ( Hamad bin Khalifa University Press (HBKU Press) , 2016 , Conference Paper)
      Background: Chronic kidney disease (CKD) is characterized by progressive decline in renal function; if left untreated, it ultimately results in end-stage renal disease (ESRD), a condition that demands either dialysis or ...

    • Anti-hypertrophic effect of Na+/H+ exchanger-1 inhibition is mediated by reduced cathepsin B 

      Sadaf, Riaz; Abdulrahman, Nabeel; Uddin, Shahab; Jabeen, Ayesha; Gadeau, Alain P.; ... more authors ( Elsevier , 2020 , Article)
      Previous studies have established the role of Na+/H+ exchanger isoform-1 (NHE1) and cathepsin B (Cat B) in the development of cardiomyocyte hypertrophy (CH). Both NHE1 and Cat B are activated under acidic conditions ...

    • Metformin Attenuates Albumin-induced Alterations in Renal Tubular Cells In Vitro 

      Allouch, Soumaya; Munusamy, Shankar ( Wiley Periodicals, Inc , 2017 , Article)
      Proteinuria (albuminuria) plays a crucial role in the etiology of chronic kidney disease (CKD) via alteration of multiple signaling pathways and cellular process in renal cells. The objectives of this study are to investigate ...

    • Nephroprotective Effects of Metformin in Diabetic Nephropathy 

      Ravindran, Sreenithya; Kuruvilla, Vinitha; Wilbur, Kerry; Munusamy, Shankar ( Wiley , 2017 , Article)
      Metformin, a well-known anti-diabetic agent, is very effective in lowering blood glucose in patients with type 2 diabetes with minimal side-effects. Metformin is also being recommended in the treatment of obesity and ...

    • Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases 

      Pasha, Mazhar; Eid, Ali H.; Eid, Assaad A.; Gorin, Yves; Munusamy, Shankar ( Hindawi , 2017 , Article)
      Sestrin2 (SESN2), a highly conserved stress-inducible metabolic protein, is known to repress reactive oxygen species (ROS) and provide cytoprotection against various noxious stimuli including genotoxic and oxidative stress, ...