Browsing Pharmacy Research by Subject "protein binding"
Now showing items 1-2 of 2
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Effect of hyperlipidemia on ketoconazole-midazolam drug-drug interaction in rat
( John Wiley & Sons, Ltd. , 2011 , Article)Hyperlipidemia (HL) was previously shown to lower liver uptake of the more potent (-) enantiomer of ketoconazole (KTZ) in rat. The current study examined the possible modifying influence of experimental HL on a KTZ ... -
Effect of rat serum lipoproteins on mRNA levels and amiodarone metabolism by cultured primary rat hepatocytes
( Wiley Periodicals, Inc. , 2013 , Article)Hyperlipidemia can significantly increase amiodarone (AM) in vivo liver uptake and decrease its velocity of microsomal metabolism. Here, hepatocytes isolated from normolipidemic (NL) and hyperlipidemic rats were incubated ...