Browsing Research Units by Subject "Vaccines"

Now showing items 1-3 of 3

    • Computational screening of known broad-spectrum antiviral small organic molecules for potential influenza HA stem inhibitors. 

      Mathew, Shilu; Al Thani, Asmaa A; Yassine, Hadi M ( Public Library of Science , 2018 , Article)
      With the emergence of new influenza virus strains that are resistant to current inhibitors such as oseltamivir (anti-neuraminidase (NA)) and amantadine (anti-M2 proton channel), influenza A viruses continue to be a serious ...

    • Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses. 

      Boyoglu-Barnum, Seyhan; Hutchinson, Geoffrey B; Boyington, Jeffrey C; Moin, Syed M; Gillespie, Rebecca A; ... more authors ( Nature Research , 2020 , Article)
      The conserved hemagglutinin (HA) stem has been a focus of universal influenza vaccine efforts. Influenza A group 1 HA stem-nanoparticles have been demonstrated to confer heterosubtypic protection in animals; however, the ...

    • Protection against Reinfection with the Omicron BA.2.75 Subvariant 

      Chemaitelly, Hiam; Tang, Patrick; Coyle, Peter; Yassine, Hadi M.; Al-Khatib, Hebah A.; ... more authors ( Massachusetts Medical Society , 2023 , Other)
      The BA.2.75 sublineage of the B.1.1.529 (omicron) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may escape neutralizing antibodies. The BA.2.75 sublineage (primarily the BA.2.75.2 subvariant) ...