• English
    • العربية
  • العربية 
  • Login
  • QU
  • QU Library
  •  Home
  • Communities & Collections
  • Help
    • Item Submission
    • Publisher policies
    • User guides
    • FAQs
  • About QSpace
    • Vision & Mission
    • QSpace policies
Advanced Search
Advanced Search
View Item 
  •   Qatar University QSpace
  • Academic
  • Faculty Contributions
  • College of Arts & Sciences
  • Biological & Environmental Sciences
  • View Item
  • Qatar University QSpace
  • Academic
  • Faculty Contributions
  • College of Arts & Sciences
  • Biological & Environmental Sciences
  • View Item
  •      
  •  
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    The Three CARMA Sisters: So Different, So Similar: A Portrait of the Three CARMA Proteins and Their Involvement in Human Disorders

    Thumbnail
    Date
    2014
    Author
    Scudiero, I.
    Vito, P.
    Stilo, R.
    Metadata
    Show full item record
    Abstract
    Initially identified by their ability to modulate the functional activity of BCL10, the three CARMA proteins, CARMA1, -2, and -3, have recently themselves taken a leading role on the stage of molecular medicine. Although considered for some time as simple ancillary proteins, increasingly accumulating recent data evidently indicate a role of primary importance for these three proteins in the pathophysiology of several human tumors and inflammatory disorders. In fact, recent scientific literature clearly establishes that CARMA1 is one of the most mutated genes in a subtype of B-cell lymphoma and, at the same time, responsible for some rare human immunodeficiency conditions. On the other hand, mutations in CARMA2 are responsible for the hereditary transmission of some inflammatory disorders of the skin, including familial psoriasis and ptiriasis; whereas expression of CARMA3 appears to be deregulated in different human tumors. Here we describe and summarize the mutations found in the genes coding for the three CARMA proteins in these different human pathological conditions, and offer an interpretation of the molecular mechanisms from which arise the biological outcomes in which these proteins are involved.

    DOI/handle
    http://dx.doi.org/10.1002/jcp.24543
    http://hdl.handle.net/10576/3700
    Collections
    • Biological & Environmental Sciences [‎320 ‎ items ]

    entitlement


    QSpace is a digital collection operated and maintained by the Qatar University Library and supported by the ITS department

    Contact Us | Send Feedback
    Contact Us | Send Feedback | QU

     

     

    Home

    Submit your QU affiliated work

    Browse

    All of QSpace
      Communities & Collections Publication Date Author Title Subject Type Language
    This Collection
      Publication Date Author Title Subject Type Language

    My Account

    Login

    Statistics

    View Usage Statistics

    About QSpace

    Vision & Mission QSpace policies

    Help

    Item Submission Publisher policiesUser guides FAQs

    QSpace is a digital collection operated and maintained by the Qatar University Library and supported by the ITS department

    Contact Us | Send Feedback
    Contact Us | Send Feedback | QU

     

     

    Video