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AuthorEl-Naggar, A. M.
AuthorAhmed, F. S. M.
AuthorEl-Salam, A. M. A.
AuthorRadi, M. A.
AuthorLatif, M. S. A.
Available date2015-11-05T11:29:51Z
Publication Date1981
Publication Namejournal of heterocyclic chemistry
CitationEl-Naggar, A. M., Ahmed, F. S. M., El-Salam, A. M. A., Radi, M. A. and Latif, M. S. A. (1981), Synthesis and biological activity of some new 3-and 6-substituted coumarin amino acid derivatives. Part I. J. Heterocyclic Chem., 18: 1203–1207.
ISSN1943-5193
URIhttp://dx.doi.org/10.1002/jhet.5570180627
URIhttp://hdl.handle.net/10576/3740
AbstractThe synthesis of 6-nitrocouarrain-3-CO-amino acids and their corresponding methyl esters (II-XVII) and some dipeptide methyl esters (XVIII-XXVI) are described. 6-(N-Tosyl- or N-phthalylaminoacyl)aminocoumarin-3-carboxylic acid methyl esters (XXXIV-XL) and 3-(N-phthalyl- or N-tosylaminoacytyaminocoumarins (XLV-LVI) have been prepared via the carbodiimide and acid chloride methods. Hydrazinolysis of 3- or 6-(N-phthalylaminoacyl)aminocoumarin derivatives in tetraline gave the corresponding 3- and 6-(aminoacyl)aminocoumarins and the carboxylic acid hydrazides (XLI-LVIII), respectively. 3-(N-Tosyl-L-Val-L-Leu-)aminocoumarin (LIX) was synthesized via the azide method. Twenty four of various substituted 3- and 6-aminoacylcoumarin derivatives were found to possess specific antimicrobial activities towards different microorganisms.
Languageen
PublisherWiley-Blackwell
SubjectAmino acids
Subjectcoumarin
TitleSynthesis and biological activity of some new 3-and 6-substituted coumarin amino acid derivatives. Part I
TypeArticle
Issue Number6
Volume Number18


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