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AuthorElleuch, Jihen
AuthorJaoua, Samir
AuthorDarriet, Frederic
AuthorChandre, Fabrice
AuthorTounsi, Slim
AuthorZribi Zghal, Raida
Available date2015-12-16T08:20:04Z
Publication Date2015-09-15
Publication NameToxiconen_US
Identifierhttp://dx.doi.org/10.1016/j.toxicon.2015.07.337
CitationCry4Ba and Cyt1Aa proteins from Bacillus thuringiensis israelensis: Interactions and toxicity mechanism against Aedes aegypti, Elleuch, Jihen; Jaoua, Samir; Darriet, Frédéric; Chandre, Fabrice; Tounsi, Slim et al., (2015) Toxicon, vol. 104, p. 83-90
ISSN0041-0101
ISSN1879-3150 (online)
URIhttp://hdl.handle.net/10576/3962
AbstractIndividual crystal proteins from Bacillus thuringiensis israelensis exhibit variable levels of insecticidal activities against mosquito larvae. In all cases, they are much less active compared to the whole crystal proteins due to described complex synergistic interactions among them. In the present study we investigated the effects of Cyt1A98 (a Cyt1Aa type protein) on Cry4BLB (a Cry4Ba type toxin) insecticidal activity toward the dengue vector Aedes aegypti. The bioassay analyses demonstrated the ability of Cyt1A98 protein to enhance Cry4BLB toxin larvicidal activity even at a low proportion in the mixture (1%). In vitro interaction assays showed that Cyt1A98 provides supplementary binding sites for Cry4BLB in A. aegypti BBMVs. Moreover, it enhances the formation of Cry4BLB oligomeric structure. These results support that Cyt1A98 protein could act as a membrane-bound receptor fixing Cry4BLB δ-endotoxins and promoting its oligomerization.
SponsorTunisian Ministry of Higher Education and Scientific Research
Languageen
PublisherElsevier Ltd.
SubjectBacillus thuringiensis israelensis
SubjectCytolytic protein Cyt1A98
SubjectCry4BLB toxin
SubjectSynergism
SubjectAedes aegypti
TitleCry4Ba and Cyt1Aa proteins from Bacillus thuringiensis israelensis: Interactions and Toxicity mechanism against Aedes aegypti
TypeArticle
Pagination83-90
Volume Number104


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