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AuthorBen Hsouna, Anis
AuthorSaoudi, Mongi
AuthorTrigui, Mohamed
AuthorJamoussi, Kamel
AuthorBoudawara, Tahia
AuthorJaoua, Samir
AuthorEl Feki, Abdelfattah
Available date2015-12-27T09:14:56Z
Publication Date2011-12
Publication NameFood and Chemical Toxicologyen_US
Identifierhttp://dx.doi.org/10.1016/j.fct.2011.09.034
Citation"Characterization of bioactive compounds and ameliorative effects of Ceratonia siliqua leaf extract against CCl4 induced hepatic oxidative damage and renal failure in rats", Hsouna, Anis Ben; Saoudi, Mongi; Trigui, Mohamed; Jamoussi, Kamel; Boudawara, Tahia, et al., (2011) Food and Chemical Toxicology vol. 49(12):p. 3183-3191
ISSN0278-6915
ISSN1873-6351 (online)
URIhttp://hdl.handle.net/10576/3992
AbstractCeratonia siliqua is a typical Mediterranean plant, mainly used in food and Tunisian traditional folk medicine. Among the tested extracts, the ethyl acetate fraction (EACs) exhibited the highest total phenolic and flavonoids content. The antioxidant activity in vitro systems showed a more significant potent free radical scavenging activity of this extract than other analysis fractions. The HPLC finger print of EACs active extract showed the presence of six phenolic compounds. The in vivo results showed that oral administration of CCl4 enhanced levels of hepatic and renal markers (ALT, AST, ALP, LDH, γ-GT, urea and creatinine) in the serum of experimental animals. It also increased the oxidative stress markers resulting in increased levels of the lipid peroxidation with a concomitant decrease in the levels of enzymatic antioxidants (SOD, CAT, GPx) in both liver and kidney. The pre-treatment of experimental rats with 250 mg/kg (BW) of the EACs, by intraperitoneal injection for 8 days, prevented CCl4 induced disorders in the levels of hepatic and kidney markers. The biochemical changes were in accordance with histopathological observations suggesting a marked hepatoprotective and nephroprotective effect of the EACs extract.
SponsorTunisian “Ministry of Higher Education, Scientific Research and Technology”
Languageen
PublisherElsevier Ltd.
SubjectPhenolic compounds
SubjectProtective effect
SubjectOxidative stress
SubjectCarbon tetrachloride
SubjectDrug-Induced Liver Injury/pathology
SubjectFlavonoids/pharmacology
SubjectLipid Peroxidation/drug effects
SubjectAlanine Transaminase/blood
TitleCharacterization of bioactive compounds and ameliorative effects of Ceratonia siliqua leaf extract against CCl4 induced hepatic oxidative damage and renal failure in rats
TypeArticle
Pagination3183-3191
Issue Number12
Volume Number49


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