Show simple item record

AuthorZotti, Tiziana
AuthorScudiero, Ivan
AuthorSettembre, Pio
AuthorFerravante, Angela
AuthorMazzone, Pellegrino
AuthorD'Andrea, Luca
AuthorReale, Carla
AuthorVito, Pasquale
AuthorStilo, Romania
Available date2016-03-24T13:39:03Z
Publication Date2014-03
Publication NameMolecular Immunology
Identifierhttp://dx.doi.org/10.1016/j.molimm.2013.10.015
CitationZotti, T., Scudiero, I., Settembre, P., Ferravante, A., Mazzone, P., D'Andrea, L., Reale, C., Vito, P., Stilo, R. "TRAF6-mediated ubiquitination of NEMO requires p62/sequestosome-1" (2014) Molecular Immunology, 58 (1), pp. 27-31.
ISSN0161-5890
URIhttp://hdl.handle.net/10576/4265
AbstractThe atypical protein kinase C-interacting protein p62/sequestosome-1 (p62) has emerged as a crucial molecule in a variety of cellular functions due to its involvement in various signaling mechanisms. p62 has been implicated in the activation of NF-?B in TNF?-stimulated cells and has been shown to be activated in response to interleukin-1? (IL-1?). Here we demonstrate that p62 interacts with NEMO, the regulatory subunit of the complex responsible for activation of NF-?B transcription factor. Depletion of p62 obtained through a short interfering RNA targeting p62 mRNA abrogated TRAF6 capacity to promote NEMO ubiquitination and severely impairs NF-?B activation following IL-1? stimulation.Together, these results indicate that p62 is an important intermediary in the NF-?B activation pathways implemented through non-degradative ubiquitination events.
SponsorTelethon Grant GGP08125B
Languageen
PublisherElsevier Ltd.
SubjectIL-1?
SubjectNF-?B
SubjectP62/sequestosome
SubjectTNF?
SubjectTRAF6
SubjectUbiquitin
TitleTRAF6-mediated ubiquitination of NEMO requires p62/sequestosome-1
TypeArticle
Pagination27-31
Issue Number1
Volume Number58


Files in this item

Icon

This item appears in the following Collection(s)

Show simple item record