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AuthorRajpoot, Kashif
AuthorRiaz, Atif
AuthorMajeed, Waqas
AuthorRajpoot, Nasir
Available date2016-03-31T14:00:57Z
Publication Date2015-08
Publication NamePLoS ONE
CitationRajpoot K, Riaz A, Majeed W, Rajpoot N (2015) Functional Connectivity Alterations in Epilepsy from Resting-State Functional MRI. PLoS ONE 10(8): e0134944.
ISSN1932-6203
URIhttp://dx.doi.org/10.1371/journal.pone.0134944
URIhttp://hdl.handle.net/10576/4295
AbstractThe study of functional brain connectivity alterations induced by neurological disorders and their analysis from resting state functional Magnetic Resonance Imaging (rfMRI) is generally considered to be a challenging task. The main challenge lies in determining and interpreting the large-scale connectivity of brain regions when studying neurological disorders such as epilepsy. We tackle this challenging task by studying the cortical region connectivity using a novel approach for clustering the rfMRI time series signals and by identifying discriminant functional connections using a novel difference statistic measure. The proposed approach is then used in conjunction with the difference statistic to conduct automatic classification experiments for epileptic and healthy subjects using the rfMRI data. Our results show that the proposed difference statistic measure has the potential to extract promising discriminant neuroimaging markers. The extracted neuroimaging markers yield 93.08% classification accuracy on unseen data as compared to 80.20% accuracy on the same dataset by a recent state-of-the-art algorithm. The results demonstrate that for epilepsy the proposed approach confirms known functional connectivity alterations between cortical regions, reveals some new connectivity alterations, suggests potential neuroimaging markers, and predicts epilepsy with high accuracy from rfMRI scans.
Languageen
PublisherPublic Library of Science
Subjectbrain function
Subjectbrain region
Subjectcontrolled study
Subjectdefault mode network
Subjectdiagnostic accuracy
Subjectdiagnostic test accuracy study
Subjectdorsal attention network
Subjectepilepsy
Subjectfocal epilepsy
Subjectfunctional connectivity
Subjectfunctional magnetic resonance imaging
Subjectgeneralized epilepsy
Subjectmajor clinical study
Subjectneuroimaging
Subjectnuclear magnetic resonance scanner
Subjectprediction
Subjectresting state functional magnetic resonance imaging
Subjectresting state network
Subjectsensitivity and specificity
Subjecttask performance
Subjecttemporal lobe epilepsy
TitleFunctional connectivity alterations in epilepsy from resting-state functional MRI
TypeArticle
Issue Number8
Volume Number10


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