Search
Now showing items 1-3 of 3
Instrumentation of Flow-Through USP IV Dissolution Apparatus to Assess Poorly Soluble Basic Drug Products: a Technical Note
(
Springer New York LLC
, 2016 , Article)
Supersaturation and precipitation are common limitations encountered especially with poorly soluble basic drugs. The aims of this work were to explore the pattern of dissolution and precipitation of poorly soluble basic ...
Studies of the precipitation pattern of paclitaxel in intravenous infusions and rat plasma using laser nephelometry
(
Taylor and Francis Ltd
, 2018 , Article)
Cremophor EL (CrEL) is commonly used to solubilize paclitaxel (Ptx); a widely established anticancer agent used against many types of cancer. Using laser-based microplate nephelometry, in this work we assessed the precipitation ...
Taxane anticancer formulations: challenges and achievements
(
Academic Press
, 2020 , Book chapter)
Taxanes represent a prominent anticancer family. Paclitaxel and docetaxel are the most well-known taxanes owing to their activity against many types of cancers. The poor solubility of taxanes in water is a major obstacle ...