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Phloretin attenuates STAT-3 activity and overcomes sorafenib resistance targeting SHP-1-mediated inhibition of STAT3 and Akt/VEGFR2 pathway in hepatocellular carcinoma
(
BioMed Central Ltd.
, 2019 , Article)
Background: Hepatocellular carcinoma (HCC) is the most common primary liver malignancy. Phloretin (PH) possesses anticancer, antitumor, and hepatoprotective effects, however, the effects and potential mechanisms of phloretin ...
Greensporone A, a fungal secondary metabolite suppressed constitutively activated AKT via ROS generation and induced apoptosis in leukemic cell lines
(
MDPI AG
, 2019 , Article)
Greensporone A is a fungal secondary metabolite that has exhibited potential in vitro for anti-proliferative activity in vitro. We studied the anticancer activity of greensporone A in a panel of leukemic cell lines. ...
Extent of extemporaneous compounding and pattern of prescribing and use of extemporaneous medicines in a developing setting
(
Blackwell Publishing Ltd
, 2019 , Article)
Objectives: To determine the extent of extemporaneous compounding, the prescribing pattern and use of extemporaneous medicines in a developing setting like Nigeria. Methods: A cross-sectional assessment was conducted at ...
Practice implications of an antimicrobial stewardship intervention in a tertiary care teaching hospital, Qatar
(
World Health Organization
, 2019 , Article)
Background: Antibiotic misuse is a worldwide public health problem and has been associated with increased morbidity, length of hospital stay, mortality, healthcare costs, and most importantly antibiotic resistance. Aims: ...
Administration error of benzathine penicillin G in a Saudi male
(
Wiley-Blackwell
, 2019 , Article)
Background
Benzathine penicillin G is indicated for intramuscular (IM ) administration. There have been reports of unintentional intravenous (IV ) administration, which has been associated with cardiorespiratory arrest ...
Clinical and Pharmacokinetic Outcomes of Peak–Trough-Based Versus Trough-Based Vancomycin Therapeutic Drug Monitoring Approaches: A Pragmatic Randomized Controlled Trial
(
Springer-Verlag France
, 2019 , Article)
Background
Vancomycin therapeutic drug monitoring (TDM) is based on achieving 24-h area under the concentration–time curve to minimum inhibitory concentration cure breakpoints (AUC24/MIC). Approaches to vancomycin TDM ...
Clinical and Economic Analysis of Morphine Versus Fentanyl in Managing Ventilated Neonates With Respiratory Distress Syndrome in the Intensive Care Setting
(
Excerpta Medica Inc.
, 2019 , Article)
Purpose: Morphine and fentanyl opioids are common analgesic agents for consideration in the neonatal intensive care unit (NICU) for neonates with respiratory distress syndrome (RDS) and undergoing mechanical ventilation ...
Multimorbidity and emergency department visits by a homeless population: a database study in specialist general practice.
(
Royal College of General Practitioners
, 2019 , Article)
Estimating healthcare needs of the homeless is associated with challenges in identifying the eligible population. To explore the demographic characteristics, disease prevalence, multimorbidity, and emergency department ...
Pass-fail decisions for borderline performers after a summative objective structured clinical examination
(
American Association of Colleges of Pharmacy
, 2019 , Article)
Objective. To determine what expert assessors value when making pass-fail decisions regarding pharmacy students based on summative data from objective structured clinical examinations (OSCE), and to determine the reliability ...
Mixed-methods approach to determine adherence, knowledge and behavioral determinants associated with medication wastage.
(
Elsevier
, 2019 , Article)
While literature quantifying medication wastage and assessing public's knowledge and practices about medication disposal is substantial, less attention is given to the public's knowledge and behavior pertaining to medication ...