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Methylated pentavalent arsenic metabolites are bifunctional inducers, as they induce cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase through AhR- and Nrf2-dependent mechanisms
(
Elsevier Inc.
, 2014 , Article)
Activation of the aryl hydrocarbon receptor (AhR) ultimately leads to the induction of the carcinogen-activating enzyme cytochrome P450 1A1 (CYP1A1), and activation of the nuclear factor-erythroid 2 p45-related factor 2 ...
Renoprotective Effects of Aldose Reductase Inhibitor Epalrestat against High Glucose-Induced Cellular Injury
(
Hindawi
, 2017 , Article)
Diabetic nephropathy (DN) is the leading cause of end stage renal disease worldwide. Increased glucose flux into the aldose reductase (AR) pathway during diabetes was reported to exert deleterious effects on the kidney. ...
Pharmacists and maternal-fetal medicine: Development of a tool to characterize knowledge and current clinical practice
(
Informa Healthcare
, 2014 , Article)
Objective: To develop a knowledge assessment tool to assess baseline knowledge and current practice regarding maternal-fetal medicine. Methods: A literature search was complemented with categorization of questions under ...
7-O-methylpunctatin, a novel homoisoflavonoid, inhibits phenotypic switch of human arteriolar smooth muscle cells
(
MDPI AG
, 2019 , Article)
Remodeling of arterioles is a pivotal event in the manifestation of many inflammation-based cardio-vasculopathologies, such as hypertension. During these remodeling events, vascular smooth muscle cells (VSMCs) switch from ...
Perception of community pharmacy personnel towards patient counseling and continuing pharmacy education programs in Aden, Yemen
(
Journal of Clinical and Diagnostic Research
, 2018 , Article)
© 2018, Journal of Clinical and Diagnostic Research. All rights reserved. Introduction: Patient counseling is a major component of pharmaceutical care, especially in community pharmacy settings. However, most community ...
Antiviral Treatment of Bell's Palsy Based on Baseline Severity: A Systematic Review and Meta-analysis
(
Elsevier
, 2015 , Article)
PurposeWe conducted a systematic review with meta-analysis to evaluate the efficacy of antiviral agents on complete recovery of Bell's palsy. MethodsWe searched CENTRAL, Embase, MEDLINE, International Pharmaceutical ...
Inhibition of p90 ribosomal S6 kinase attenuates cell migration and proliferation of the human lung adenocarcinoma through phospho-GSK-3β and osteopontin
(
Springer-Verlag
, 2016 , Article)
p90 ribosomal S6 kinase (p90RSK) constitutes a family of serine/threonine kinases that have been shown to be involved in cell proliferation of various malignancies via direct or indirect effects on the cell-cycle machinery. ...
Na+/H+ exchanger isoform 1 induced osteopontin expression in cardiomyocytes involves NFAT3/Gata4
(
Springer-Verlag
, 2015 , Article)
Osteopontin (OPN), a multifunctional glycophosphoprotein, has been reported to contribute to the development and progression of cardiac remodeling and hypertrophy. Cardiac-specific OPN knockout mice were protected against ...
Changes in student perceptions after a semester-long interprofessional education activity in Qatar
(
Elsevier
, 2016 , Article)
Objectives Interprofessional education (IPE) is rapidly becoming integrated into university accreditation standards worldwide. However, the impact of IPE on student learning and practice is largely unknown in the Middle ...
Bridging theory and practice: Mixed methods approach to instruction of law and ethics within the pharmaceutical sciences
(
Elsevier
, 2016 , Article)
Background: Professional responsibilities are guided by laws and ethics that must be introduced and mastered within pharmaceutical sciences training. Instructional design to teaching typically introduces concepts in a ...