Browsing Biomedical Sciences by Title
Now showing items 577-596 of 641
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Taxane formulations: From plant to clinic
( Springer International Publishing , 2017 , Book chapter)Taxanes including paclitaxel and docetaxel are highly active against many types of cancers. The main obstacle with developing delivery systems of taxanes is their poor water solubility. In this chapter, taxanes were reviewed ... -
Testing the Anticancer Effect of Matcha Using Zebrafish as an Animal Model
( MDPI , 2023 , Article)Cancer is the second leading cause of death worldwide, and triple-negative breast cancer (TNBC) patients show the poorest prognosis and survival and the highest metastasis prevalence among all breast cancer subtypes. Matcha ... -
Testosterone treatment and change of categories of the International prostate symptom score (IPSS) in hypogonadal patients: 12 years prospective controlled registry study
( Taylor and Francis Ltd. , 2023 , Article)Functional hypogonadism is a condition characterized by low testosterone concentrations, occurring more commonly in men as they age. The International Prostate Symptom Score (IPSS) is used to categorize the severity of ... -
The Association of Hypertension with Increased Mortality Rate During the COVID-19 Pandemic: An Update with Meta-analysis
( Springer Science and Business Media B.V. , 2023 , Article Review)Background and Aim The impact of multiple risk factors on COVID-19 mortality has been previously reported in multiple systematic reviews and meta-analyses. The aim of this review is to provide a comprehensive update on ... -
The hypertensive potential of estrogen: An untold story
( Elsevier , 2020 , Article Review)Cardiovascular disease (CVD) is the major cause of morbidity and mortality worldwide. The implication of estrogen in this disease has been extensively studied. While the vast majority of published research argue for a ... -
The Immunomodulatory Role of Microbiota in Rheumatic Heart Disease: What Do We Know and What Can We Learn from Other Rheumatic Diseases?
( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article Review)Rheumatic heart disease (RHD) represents a serious cardiac sequela of acute rheumatic fever, occurring in 30-45% of patients. RHD is multifactorial, with a strong familial predisposition and known environmental risk factors ... -
The Impact of ACE Gene Variants on Acute-Phase Reactants in Children with Rheumatic Heart Disease
( MDPI , 2023 , Article)Rheumatic heart disease (RHD) is the most important sequela of upper respiratory group A Streptococcus (GAS) infection. The role of the common angiotensin-converting enzyme (ACE) insertion/deletion (I/D) variant in the ... -
The impact of COVID-19 pandemic lockdown on smoking habits and lifestyle: A cross-sectional study
( John Wiley and Sons Inc , 2023 , Article)Background and Aims: Throughout the COVID-19 lockdown, the resultant psychological disturbances led to more tobacco consumption and deteriorated smoking behaviors among smokers. In this study, we aimed to investigate the ... -
The Impact of Diabetes on Pregnancy in Qatar
( Hamad bin Khalifa University Press (HBKU Press) , 2009 , Article)Objectives: To investigate maternal and neonatal outcomes of pregnancies in women with different types of diabetes in Qatar. To identify factors such as age, family history of diabetes and obesity contributing to the ... -
The Implementation of an Integrated Management System at Qatar Biobank
( Mary Ann Liebert Inc. , 2019 , Article)Qatar Biobank (QBB) is a platform that will make vital health research possible through its collection of samples and information on health and lifestyle from the local population of Qatar. The goal of QBB is to collect, ... -
The mitochondria: A target of polyphenols in the treatment of diabetic cardiomyopathy
( MDPI , 2020 , Article)Diabetic cardiomyopathy (DCM) is a constellation of symptoms consisting of ventricular dysfunction and cardiomyocyte disarray in the presence of diabetes. The exact cause of this type of cardiomyopathy is still unknown; ... -
The potential role of vitamin D supplementation as a gut microbiota modifier in healthy individuals
( Nature Research , 2020 , Article)Vitamin D deficiency affects approximately 80% of individuals in some countries and has been linked with gut dysbiosis and inflammation. While the benefits of vitamin D supplementation on the gut microbiota have been studied ... -
The Qatari population's genetic structure and gene flow as revealed by the Y chromosome
( Public Library of Science , 2023 , Article)The Y-chromosome has been widely used in forensic genetic applications and human population genetic studies due to its uniparental origins. A large database on the Qatari population was created for comparison with other ... -
The role of Rezum in the management of refractory urinary retention due to benign prostate hyperplasia: A literature review
( Taylor and Francis Ltd. , 2023 , Article)Background: Benign prostatic hyperplasia is the most common cause of urinary retention in men (BPH). The gold standard surgical treatment is transurethral resection of the prostate (TURP). However, due to the morbidity and ... -
The Role of Soluble Adhesion Molecules in Type 2 Diabetes Mellitus
( Hamad bin Khalifa University Press (HBKU Press) , 2018 , Conference Paper)Background: Diabetes mellitus (DM) is a chronic metabolic disorder that is steadily increasing worldwide and is a leading cause of morbidity and mortality. As reported by the World Health Organization (WHO), 346 million ... -
The role of α2-adrenergic receptors in hypertensive preeclampsia: A hypothesis
( Wiley Blackwell , 2019 , Article Review)Preeclampsia, a major disorder of human pregnancy, manifests as persistent hypertension and proteinuria presenting after 20 weeks of pregnancy. Multiple systemic symptoms might be associated with preeclampsia including ... -
The spectrum of chromosomal translocations in the Arab world: ethnic-specific chromosomal translocations and their relevance to diseases
( Springer Science and Business Media Deutschland GmbH , 2022 , Article Review)Chromosomal translocations (CTs) are the most common type of structural chromosomal abnormalities in humans. CTs have been reported in several studies in the Arab world, but the frequency and spectrum of these translocations ... -
The Spectrum of Genetic Variants Associated with the Development of Monogenic Obesity in Qatar
( S. Karger AG , 2022 , Article)Introduction: Monogenic obesity (MO) is a rare genetic disease characterized by severe early-onset obesity in affected individuals. Previous genetic studies revealed 8 definitive genes for monogenic non-syndromic obesity; ... -
The Therapeutic Role of Curcumin in Inflammation and Post-Surgical Outcomes
( Taylor and Francis Ltd. , 2023 , Article Review)Curcumin (diferuloylmethane) is a natural polyphenolic compound that targets multiple signaling molecules and helps in supporting health benefits as it aids in the management of oxidative and inflammatory conditions. ... -
Therapeutic and diagnostic applications of exosomal circRNAs in breast cancer
( Institute for Ionics , 2023 , Article Review)Circular RNAs (circRNAs) are regulatory elements that are involved in orchestrating gene expression and protein functions and are implicated in various biological processes including cancer. Notably, breast cancer has a ...