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Durable immunity to oncogenic human papillomaviruses elicited by adjuvanted recombinant Adeno-associated virus-like particle immunogen displaying L2 17-36 epitopes
(
Elsevier
, 2015 , Article)
Vaccination with the minor capsid protein L2, notably the 17–36 neutralizing epitope, induces broadly protective antibodies, although the neutralizing titers attained in serum are substantially lower than for the licensed ...
Genotype-phenotype correlation in patients with isovaleric acidaemia: comparative structural modelling and computational analysis of novel variants.
(
Oxford University Press (OUP)
, 2017 , Article)
Isovaleric acidaemia (IVA) is an autosomal recessive inborn error of leucine metabolism. It is caused by a deficiency in the mitochondrial isovaleryl-CoA dehydrogenase (IVD) enzyme. In this study, we investigated eight ...
Genetic Epidemiology of Hearing Loss in the 22 Arab Countries: A Systematic Review
(
Wolters Kluwer Health
, 2019 , Article)
Hearing loss (HL) is a heterogeneous condition that causes partial or complete hearing impairment. Hundreds of variants in more than 60 genes have been reported to be associated with Hereditary HL (HHL). The HHL prevalence ...
Profiling the Oral Microbiome and Plasma Biochemistry of Obese Hyperglycemic Subjects in Qatar
(
MDPI
, 2019 , Article)
The present study is designed to compare demographic characteristics, plasma biochemistry, and the oral microbiome in obese (N = 37) and lean control (N = 36) subjects enrolled at Qatar Biobank, Qatar. Plasma hormones, ...
Nox2 activity is required in obesity-mediated alteration of bone remodeling
(
Hindawi Limited
, 2018 , Article)
Despite increasing evidence suggesting a role for NADPH oxidases (Nox) in bone pathophysiology, whether Nox enzymes contribute to obesity-mediated bone remodeling remains to be clearly elucidated. Nox2 is one of the ...
Cysteamine revisited: repair of arginine to cysteine mutations.
(
Springer Verlag
, 2017 , Article)
Cysteamine is a small aminothiol endogenously derived from coenzyme A degradation. For some decades, synthetic cysteamine has been employed for the treatment of cystinosis, and new uses of the drug continue to emerge. In ...
New markers for the detection of polycystic ovary syndrome
(
MedCrave Group
, 2019 , Article)
Polycystic Ovary Syndrome (PCOS) is a highly prevalent, complex genetic disorder of the endocrine system in women. Alterations that occur in women with PCOS can be due to several predisposing factors; among these contributors ...
Epstein–Barr Virus Epidemiology, Serology, and Genetic Variability of LMP-1 Oncogene Among Healthy Population: An Update
(
Frontiers Medi
, 2018 , Article Review)
The Epstein–Barr virus (EBV) is a DNA lymphotropic herpesvirus and the causative agent
of infectious mononucleosis. EBV is highly prevalent since it affects more than 90% of
individuals worldwide and has been linked to ...
The frequency of polycystic ovary syndrome in young reproductive females in Qatar
(
Dove Medical Press
, 2016 , Article)
This was a prospective cross-sectional study in which 126 female students between the ages of 18 and 30 years were evaluated for the frequency of polycystic ovary syndrome (PCOS) through clinical interview, questionnaire, ...
Platelets as a Possible Reservoir of HCV And Predictor of Response to Treatment
(
SciTechnol
, 2016 , Article)
In the era of new Hepatitis C Virus (HCV) therapy, and the detection of
extrahepatic HCV reservoirs such as peripheral blood mononuclear
cells and platelets, it is important to understand the factors underlying
resistance ...