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AuthorArshad, Muhammad
AuthorSiddiqa, Maryam
AuthorRashid, Saddaf
AuthorHashmi, Imran
AuthorAwan, Muhammad Ali
AuthorAli, Muhammad Arif
Available date2016-10-19T07:05:27Z
Publication Date2016-06
Publication NameSafety and Health at Worken_US
Identifierhttp://dx.doi.org/10.1016/j.shaw.2015.11.001
CitationMuhammad Arshad, Maryam Siddiqa, Saddaf Rashid, Imran Hashmi, Muhammad Ali Awan, Muhammad Arif Ali, Biomonitoring of Toxic Effects of Pesticides in Occupationally Exposed Individuals, Safety and Health at Work, Volume 7, Issue 2, June 2016, Pages 156-160,
ISSN20937911
URIhttp://www.sciencedirect.com/science/article/pii/S2093791115000943
URIhttp://hdl.handle.net/10576/4903
AbstractBackground Workers in pesticide manufacturing industries are constantly exposed to pesticides. Genetic biomonitoring provides an early identification of potential cancer and genetic diseases in exposed populations. The objectives of this biomonitoring study were to assess DNA damage through comet assay in blood samples collected from industry workers and compare these results with those of classical analytical techniques used for complete blood count analysis. Methods Samples from controls (n = 20) and exposed workers (n = 38) from an industrial area in Multan, Pakistan, were subjected to various tests. Malathion residues in blood samples were measured by gas chromatography. Results The exposed workers who were employed in the pesticide manufacturing industry for a longer period (i.e., 13–25 years) had significantly higher DNA tail length (7.04 μm) than the controls (0.94 μm). Workers in the exposed group also had higher white blood cell and red blood cell counts, and lower levels of mean corpuscular hemoglobin (MCH), MCH concentration, and mean corpuscular volume in comparison with normal levels for these parameters. Malathion was not detected in the control group. However, in the exposed group, 72% of whole blood samples had malathion with a mean value of 0.14 mg/L (range 0.01–0.31 mg/L). Conclusion We found a strong correlation (R2 = 0.91) between DNA damage in terms of tail length and malathion concentration in blood. Intensive efforts and trainings are thus required to build awareness about safety practices and to change industrial workers' attitude to prevent harmful environmental and anthropogenic effects.
SponsorHigher Education Commission of Pakistan (Grant No. PM-IPFP/HRD/HEC/2010/1501). Open Access funded by Occupational Safety and Health Research Institute
Languageen
PublisherElsevier
Subjectcomet assay
SubjectDNA damage
Subjectgenotoxicity
Subjecthematological tests
Subjectmalathion
TitleBiomonitoring of Toxic Effects of Pesticides in Occupationally Exposed Individuals
TypeArticle
Pagination156-160
Issue Number2
Volume Number7
Open Access user License http://creativecommons.org/licenses/by-nc-nd/4.0/


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