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المؤلفMarei, H.
المؤلفElnegiry, A.
المؤلفZaghloul, A.
المؤلفAlthani, A.
المؤلفAfifi, N.
المؤلفAbd-Elmaksoud, A.
المؤلفFarag, A.
المؤلفLashen, S.
المؤلفRezk, S.
المؤلفShouman, Z.
المؤلفCenciarelli, C.
المؤلفHasan, A.
تاريخ الإتاحة2017-02-13T08:31:39Z
تاريخ النشر2017-01-25
اسم المنشورJournal of Cellular Physiologyen_US
المعرّفhttp://dx.doi.org/10.1002/jcp.25826
الاقتباسMarei, H., Elnegiry, A., Zaghloul, A., Althani, A., Afifi, N., Abd-Elmaksoud, A., Farag, A., Lashen, S., Rezk, S., Shouman, Z., Cenciarelli, C. and Hasan, A. (2017), Nanotubes Impregnated Human Olfactory Bulb Neural Stem Cells Promote Neuronal Differentiation in Trimethyltin-induced Neurodegeneration Rat Model. J. Cell. Physiol.
الرقم المعياري الدولي للكتاب0021-9541
معرّف المصادر الموحدhttp://hdl.handle.net/10576/5243
الملخصNeural stem cells (NSCs) are multipotent self-renewing cells that could be used in cellular-based therapy for a wide variety of neurodegenerative diseases including Alzheimer's diseases (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). Being multipotent in nature, they are practically capable of giving rise to major cell types of the nervous tissue including neurons, astrocytes and oligodendrocytes. This is in marked contrast to neural progenitor cells which are committed to a specific lineage fate. In previous studies, we have demonstrated the ability of NSCs isolated from human olfactory bulb (OB) to survive, proliferate, differentiate, and restore cognitive and motor deficits associated with AD, and PD rat models, respectively. The use of carbon nanotubes (CNTs) to enhance the survivability and differentiation potential of NSCs following their in vivo engraftment have been recently suggested. Here, in order to assess the ability of CNTs to enhance the therapeutic potential of human OBNSCs for restoring cognitive deficits and neurodegenerative lesions, we co-engrafted CNTs and human OBNSCs in TMT-neurodegeneration rat model. The present study revealed that engrafted human OBNSCS-CNTs restored cognitive deficits, and neurodegenerative changes associated with TMT-induced rat neurodegeneration model. Moreover, the CNTs seemed to provide a support for engrafted OBNSCs, with increasing their tendency to differentiate into neurons rather than into glia cells. The present study indicate the marked ability of CNTs to enhance the therapeutic potential of human OBNSCs which qualify this novel therapeutic paradigm as a promising candidate for cell-based therapy of different neurodegenerative diseases.
اللغةen
الناشرWiley
الموضوعolfactory bulb
الموضوعneural stem cells
الموضوعcarbon nanotubes (CNTs
الموضوعcellular - based therapy
العنوانNanotubes Impregnated Human Olfactory Bulb Neural Stem Cells Promote Neuronal Differentiation in Trimethyltin-induced Neurodegeneration Rat Model
النوعArticle
الصفحات57-63
رقم المجلد164
ESSN1097-4652


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