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AuthorGaravelo, Shérrira M
AuthorHiguchi, Maria de Lourdes
AuthorPereira, Jaqueline J
AuthorReis, Marcia M
AuthorKawakami, Joyce T
AuthorIkegami, Renata N
AuthorPalomino, Suely AP
AuthorWadt, Nilsa S Y
AuthorAgouni, Abdelali
Available date2017-02-28T10:38:31Z
Publication Date2017-02-27
Publication NameBioMed Research International
Identifierhttp://dx.doi.org/10.1155/2017/7212985
CitationShérrira M. Garavelo, Maria de Lourdes Higuchi, Jaqueline J. Pereira, et al., “Comparison of the Protective Effects of Individual Components of Particulated trans-Sialidase (PTCTS), PTC and TS, against High Cholesterol Diet-Induced Atherosclerosis in Rabbits,” BioMed Research International, vol. 2017, Article ID 7212985, 12 pages, 2017.
ISSN2314-6133
IdentifierArticle ID 7212985
URIhttp://hdl.handle.net/10576/5319
AbstractPrevious studies showed the presence of Mycoplasma pneumoniae (M. pneumoniae) and membrane-shed microparticles (MPs) in vulnerable atherosclerotic plaques. H&S Science and Biotechnology developed PTCTS, composed by natural particles from medicinal plants (PTC) combined with trans-Sialidase (TS), to combat MPs and Mycoplasma pneumoniae. Our aim was to determine the effects of the different components of PTCTS in a rabbit model of atherosclerosis. Rabbits were fed with high cholesterol diet for 12 weeks and treated during the last 6 weeks with either vehicle, PTC, TS, or PTCTS. Lipid profile and quantification of MPs positive for Mycoplasma pneumoniae and oxidized LDL antigens were carried out. Aortas and organs were then histologically analyzed. PTCTS reduced circulating MPs positive for Mycoplasma pneumoniae and oxidized LDL antigens, reduced the plaque area in the abdominal aorta, and caused positive remodeling of the ascendant aorta. PTC caused positive remodeling and reduced plaque area in the abdominal aorta; however, TS had a lipid lowering effect. PTCTS components combined were more effective against atherosclerosis than individual components. Our data reinforce the infectious theory of atherosclerosis and underscore the potential role of circulating MPs. Therefore, the removal of Mycoplasma-derived MPs could be a new therapeutic approach in the treatment of atherosclerosis.
SponsorThis work was supported by Grant no. 2012/12656-5 from FAPESP (Fundac¸ao de Amparo ˜ a Pesquisa do Estadode `Sao Paulo) to Professor Maria de Lourdes Higuchi and by a ˜mobility grant from Banco Santander to Dr. Abdelali Agouni.
Languageen
PublisherHindawi Publishing Corporation
Subjectatherosclerosis
Nanoparticles
Microparticles
TitleComparison of the Protective Effects of Individual Components of Particulated trans-Sialidase (PTCTS), PTC and TS, against High Cholesterol Diet-Induced Atherosclerosis in Rabbits
TypeArticle
Volume Number2017
ESSN2314-6141


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