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AuthorShanmugakonar, Muralitharan
AuthorVaradharajan, Kavitha
AuthorVito, Pasquale
Available date2017-05-01T07:31:20Z
Publication Date2016-11
CitationShanmugakonar, Muralitharan; Varadharajan, Kavitha; Vito, Pasquale "Expression of active and inactive forms of CIK and CARMA 2sh proteins in Normal Human Epidermal Keratinocytes (NHEK)" 3rd Middle East Molecular Biology Congress & Exhibition 2016 - Doha, November 14-17
URIhttp://hdl.handle.net/10576/5478
AbstractPsoriasis is a debilitating skin disease affecting approximately 23% of human population. The disease is considered to have key genetic underpinning and genome wide association studies and meta analysis have identified more than 40 susceptibility loci for psoriasis. CARMA proteins play a major role in regulating activation of transcription factor NF-kB which is ubiquitously expressed in mammalian cells that play a central role in the control of immune and inflammatory response. Missense mutations in the CARMA2 gene have been shown to dominantly transmit the psoriatic trait with high penetrance. Most of the CARMA2 mutations associated with skin disorders clusters in the coiled coil domain of the protein.
SponsorNPRP 7-466-3-119 from the Qatar National Research Fund of Qatar Foundation
Languageen
SubjectNF-kB
SubjectKeratinocytes
SubjectCARMA2sh
SubjectCIK
SubjectPsoriasis
TitleExpression of active and inactive forms of CIK and CARMA 2sh proteins in Normal Human Epidermal Keratinocytes (NHEK)
TypePoster


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