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المؤلفShanmugakonar, Muralitharan
المؤلفVaradharajan, Kavitha
المؤلفVito, Pasquale
تاريخ الإتاحة2017-05-14T06:55:36Z
تاريخ النشر2017-05-03
الاقتباسShanmugakonar, Muralitharan; Varadharajan, Kavitha; Vito, Pasquale "Effect of CARMA 2sh gene in Mouse embryonic stem (ES) cells" Qatar University Annual Research Forum (2017), Doha May 3-4
معرّف المصادر الموحدhttp://hdl.handle.net/10576/5492
الملخصCARMA2 belongs to the CARMA family of proteins. They are involved in the regulation and activation of NF-κB that have a central role in the control of immune and inflammatory response, and cell survival and proliferation. CARMA2short (CARMA2sh) which is the most prominent CARMA2 isoform expressed in human keratinocytes. It has already been identified that CARMA2sh induces activation of NF-κB, and this activity requires the function of another CARD-containing protein, namely BCL10, and the adapter protein TRAF2. This study identified a CARMA Inhibitory Kinase (CIK) which inhibit the ability to induce NF-κB. CIK is not tested for their function in Human Primary keratinocytes and hence we attempt to understand the function of CIK and its associated molecules by invitro and invivo models. The inhibitory activity of CIK on CARMA2 in primary human keratinocytes expressing wild (wt) & mutant CARMA2 was analyzed.
راعي المشروعThis work was made possible by NPRP grant NPRP 7 - 466 - 3119 from the Qatar National Research Fund of Qatar Foundation
اللغةen
الموضوعTransgenic mice
الموضوعCARMA 2sh
الموضوعES cells
الموضوعNHEK
الموضوعRT-PCR
العنوانEffect of CARMA 2sh gene in Mouse embryonic stem (ES) cells
النوعPoster


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