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AuthorSotgia, Salvatore
AuthorZinellu, Angelo
AuthorMangoni, Arduino A
AuthorSerra, Roberta
AuthorPintus, Gianfranco
AuthorCaruso, Calogero
AuthorDeiana, Luca
AuthorCarru, Ciriaco
Available date2017-11-14T10:29:08Z
Publication Date2017-12-01
Publication NameExperimental Gerontologyen_US
Identifierhttp://dx.doi.org/10.1016/j.exger.2017.10.005
CitationSotgia, S., Zinellu, A., Mangoni, A. A., Serra, R., Pintus, G., Caruso, C., Deiana, L. and Carru, C. (2017)"Cellular immune activation in Sardinian middle-aged, older adults and centenarians" Experimental Gerontology, vol.99, pp. 133-137.
ISSN0531-5565
URIhttp://hdl.handle.net/10576/5751
AbstractIn addition to viral infections, malignant disorders, autoimmune diseases, and allograft rejection episodes, neopterin increases in older people where it is found to be predictive of overall mortality. Thus, the serum concentrations of this biomarker of systemic immune and inflammation activation, were measured in a small cohort of Sardinian middle-aged, older adults and centenarians. There was a significant positive correlation between neopterin concentrations and age with the subjects in the 95-year-old group with the highest values. Notably, the group of centenarians had neopterin values comparable to those of 80- and 90-year-old groups, and significantly lower than that of 95-year-old group. This suggests a decreased monocyte/macrophage-mediated immune activation and an apparently preserved immune status in centenarians.
Languageen
PublisherElsevier
SubjectInflammaging
SubjectPteridines
SubjectAging
SubjectImmunosenescence
SubjectLongevity
SubjectCentenarians
SubjectCytokines
TitleCellular immune activation in Sardinian middle-aged, older adults and centenarians
TypeArticle
Pagination133-137
Volume Number99
ESSN1873-6815


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