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AuthorKnaus, Martin
AuthorAbu-Madi, Marawan A
AuthorIbarra-Velarde, Froylán
AuthorKok, Dawie J
AuthorKusi, Ilir
AuthorPostoli, Rezart
AuthorChester, S Theodore
AuthorRosentel, Joseph
AuthorAlva, Roberto
AuthorIrwin, Jennifer
AuthorVisser, Martin
AuthorWinter, Renate
AuthorRehbein, Steffen
Available date2018-01-22T09:44:16Z
Publication Date2014-04-01
Publication NameVeterinary Parasitologyen_US
Identifierhttp://dx.doi.org/10.1016/j.vetpar.2014.02.033
CitationM. Knaus et al. Efficacy of a novel topical fipronil, (S)-methoprene, eprinomectin and praziquantel combination against naturally acquired intestinal nematode and cestode infections in cats.. Veterinary Parasitology. 2014 Apr 28;202(1-2):18-25. doi: 10.1016/j.vetpar.2014.02.033.
URIhttp://hdl.handle.net/10576/6170
AbstractThe efficacy of a novel topical combination formulation of fipronil, (S)-methoprene, eprinomectin and praziquantel against naturally acquired intestinal nematode and cestode infections in cats was evaluated in seven negative control, blinded studies. Cats were selected based on a pre-treatment faecal examination indicating a patent infection with at least hookworms (two studies), Toxocara ascarids (one study), taeniid cestodes (two studies) or Dipylidium cestodes (two studies). In each study, cats were assigned randomly to blocks of two animals each, based on decreasing pre-treatment body weight and were randomly allocated to one of two groups of six to 12 cats: untreated (control) or treated with topical fipronil (8.3%, w/v), (S)-methoprene (10%, w/v), eprinomectin (0.4%, w/v) and praziquantel (8.3%, w/v) (BROADLINE(®), Merial) at 0.12 mL/kg body weight (providing a minimum of 10mg fipronil+12 mg S-methoprene+0.5mg eprinomectin+10mg praziquantel per kg body weight). The topical treatment was administered directly on the skin in the midline of the neck in a single spot once on Day 0. For parasite recovery and count, cats were euthanized humanely and necropsied seven or ten days after treatment. A single treatment with the novel topical combination product provided 91% efficacy against Ancylostoma braziliense, ≥ 99% efficacy against Ancylostoma tubaeforme, and >97% efficacy against Toxocara cati. Similarly, excellent efficacy was established against Taenia taeniaeformis, Dipylidium caninum and Diplopylidium spp. as demonstrated by >97% and up to 100% reductions of cestode counts in the treated cats when compared to the untreated controls (P<0.01). All cats accepted the treatment well based on health observations post-treatment and daily health observations. No adverse experiences or other health problems were observed throughout the studies. The results of this series of controlled studies demonstrated high efficacy and excellent acceptability of the novel topical combination formulation of fipronil, (S)-methoprene, eprinomectin and praziquantel against a broad range of feline intestinal nematode and cestode infections.
Languageen
PublisherElsevier
SubjectAncylostoma braziliense
SubjectAncylostoma tubaeforme
SubjectDiplopylidium spp.
SubjectDipylidium caninum
SubjectTaenia taeniaeformis
SubjectToxocara cati
TitleEfficacy of a novel topical fipronil, (S)-methoprene, eprinomectin and praziquantel combination against naturally acquired intestinal nematode and cestode infections in cats.
TypeArticle
Pagination18 - 25
Issue Number1-2
Volume Number202


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