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    Enhanced Identification of Transcriptional Enhancers Provides Mechanistic Insights into Diseases.

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    Date
    2016-02-01
    Author
    Murakawa, Y
    Yoshihara, M
    Kawaji, H.
    Nishikawa, M
    Zayed, Hatem
    Suzuki H, Fantom Consortium, Hayashizaki Y.
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    Abstract
    Enhancers are distal cis-regulatory DNA elements that increase the expression of target genes. Various experimental and computational approaches including chromatin signature profiling have been developed to predict enhancers on a genome-wide scale, although each method has its advantages and disadvantages. Here we overview an emerging method to identify transcribed enhancers at exceedingly high nucleotide resolution based on enhancer RNA transcripts captured by Cap Analysis of Gene Expression (CAGE) technology. We further argue that disease-causative regulatory mutations at enhancers are increasingly recognized, emphasizing the importance of enhancer identification in functional and clinical genomics including, but not limited to, genome-wide association studies (GWASs) and cancer genomics studies.
    DOI/handle
    http://dx.doi.org/10.1016/j.tig.2015.11.004
    http://hdl.handle.net/10576/6297
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    • Biomedical Sciences [‎268 ‎ items ]

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