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AuthorMarei, Hany E
AuthorHasan, A
AuthorRizzi, R
AuthorAlthani, A
AuthorAfifi, N
AuthorCenciarelli, C
AuthorCaceci, Thomas
AuthorShuaib, Ashfaq
Available date2018-02-27T05:04:50Z
Publication Date2018-02-06
Publication NameFrontiers in Neurologyen_US
Identifierhttp://dx.doi.org/10.3389/fneur.2018.00034
CitationMarei HE, Hasan A, Rizzi R, Althani A, Afifi N, Cenciarelli C, Caceci T and Shuaib A (2018) Potential of Stem Cell-Based Therapy for Ischemic Stroke. Front. Neurol. 9:34. doi: 10.3389/fneur.2018.00034
URIhttp://hdl.handle.net/10576/6406
AbstractIschemic stroke is one of the major health problems worldwide. The only FDA approved anti-thrombotic drug for acute ischemic stroke is the tissue plasminogen activator. Several studies have been devoted to assessing the therapeutic potential of different types of stem cells such as neural stem cells (NSCs), mesenchymal stem cells, embryonic stem cells, and human induced pluripotent stem cell-derived NSCs as treatments for ischemic stroke. The results of these studies are intriguing but many of them have presented conflicting results. Additionally, the mechanism(s) by which engrafted stem/progenitor cells exert their actions are to a large extent unknown. In this review, we will provide a synopsis of different preclinical and clinical studies related to the use of stem cell-based stroke therapy, and explore possible beneficial/detrimental outcomes associated with the use of different types of stem cells. Due to limited/short time window implemented in most of the recorded clinical trials about the use of stem cells as potential therapeutic intervention for stroke, further clinical trials evaluating the efficacy of the intervention in a longer time window after cellular engraftments are still needed.
SponsorGCC-2017-004 Internal Grant Qatar University
Languageen
PublisherFrontiers Media
Subjectinduced pluripotent stem cells
Subjectischemic stroke
Subjectmesenchymal stem cell
Subjectneural stem cell
Subjectstem cell
TitlePotential of Stem Cell-Based Therapy for Ischemic Stroke.
TypeArticle
Pagination1-7
Volume Number9
dc.identifier.essn 1664-2295


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