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AuthorHasan, Anwarul
AuthorSoliman, Sherif
AuthorEl Hajj, Fatima
AuthorTseng, Yuan-Tsan
AuthorYalcin, Huseyin C
AuthorMarei, Hany Elsayed
Available date2018-06-27T05:27:42Z
Publication Date2018-05-01
Publication NameScientific Reportsen_US
Identifierhttp://dx.doi.org/10.1038/s41598-018-26452-y
CitationHasan A, Soliman S, El Hajj F, Tseng Y-T, Yalcin HC, Marei HE. Fabrication and In Vitro Characterization of a Tissue Engineered PCL-PLLA Heart Valve. Scientific Reports. 2018;8:8187. doi:10.1038/s41598-018-26452-y.
ISSN2045-2322
URIhttp://hdl.handle.net/10576/6751
AbstractHeart valve diseases are among the leading causes of cardiac failure around the globe. Nearly 90,000 heart valve replacements occur in the USA annually. Currently, available options for heart valve replacement include bioprosthetic and mechanical valves, both of which have severe limitations. Bioprosthetic valves can last for only 10-20 years while patients with mechanical valves always require blood-thinning medications throughout the remainder of the patient's life. Tissue engineering has emerged as a promising solution for the development of a viable, biocompatible and durable heart valve; however, a human implantable tissue engineered heart valve is yet to be achieved. In this study, a tri-leaflet heart valve structure is developed using electrospun polycaprolactone (PCL) and poly L-lactic acid (PLLA) scaffolds, and a set of in vitro testing protocol has been developed for routine manufacturing of tissue engineered heart valves. Stress-strain curves were obtained for mechanical characterization of different valves. The performances of the developed valves were hemodynamically tested using a pulse duplicator, and an echocardiography machine. Results confirmed the superiority of the PCL-PLLA heart valve compared to pure PCL or pure PLLA. The developed in vitro test protocol involving pulse duplicator and echocardiography tests have enormous potential for routine application in tissue engineering of heart valves.
Languageen
PublisherNature Publishing Group
SubjectPCL-PLLA
SubjectTissue engineering
SubjectPolycaprolactone
SubjectCoronary heart disease
SubjectSurgeons
SubjectPolylactic acid
SubjectEchocardiography
SubjectCatheters
SubjectValves
SubjectHeart diseases
TitleFabrication and In Vitro Characterization of a Tissue Engineered PCL-PLLA Heart Valve.
TypeArticle
Pagination1-13
Issue Number1
Volume Number8
dc.identifier.essn 2045-2322


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