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AuthorSmatti, Maria K
AuthorAl-Sadeq, Duaa W
AuthorAli, Nadima H
AuthorPintus, Gianfranco
AuthorAbou-Saleh, Haissam
AuthorNasrallah, Gheyath K
Available date2018-08-07T10:31:47Z
Publication Date2018-06-13
Publication NameFrontiers in Oncologyen_US
Identifierhttp://dx.doi.org/10.3389/fonc.2018.00211
CitationSmatti MK, Al-Sadeq DW, Ali NH, Pintus G, Abou-Saleh H and Nasrallah GK (2018) Epstein–Barr Virus Epidemiology, Serology, and Genetic Variability of LMP-1 Oncogene Among Healthy Population: An Update. Front. Oncol. 8:211. doi: 10.3389/fonc.2018.00211
URIhttp://hdl.handle.net/10576/6826
AbstractThe Epstein-Barr virus (EBV) is a DNA lymphotropic herpesvirus and the causative agent of infectious mononucleosis. EBV is highly prevalent since it affects more than 90% of individuals worldwide and has been linked to several malignancies including PTLDs, which are one of the most common malignancies following transplantation. Among all the EBV genes, most of the recent investigations focused on studying the LMP-1 oncogene because of its high degree of polymorphism and association with tumorigenic activity. There are two main EBV genotypes, Type 1 and 2, distinguished by the differences in the EBNA-2 gene. Further sub genotyping can be characterized by analyzing the LMP-1 gene variation. The virus primarily transmits through oral secretions and persists as a latent infection in human B-cells. However, it can be transmitted through organ transplantations and blood transfusions. In addition, symptoms of EBV infection are not distinguishable from other viral infections, and therefore, it remains questionable whether there is a need to screen for EBV prior to blood transfusion. Although the process of leukoreduction decreases the viral copies present in the leukocytes, it does not eliminate the risk of EBV transmission through blood products. Here, we provide a review of the EBV epidemiology and the genetic variability of the oncogene LMP-1. Then, we underscore the findings of recent EBV seroprevalence and viremia studies among blood donors as a highly prevalent transfusion transmissible oncovirus.
Languageen
PublisherFrontiers Media
SubjectEpstein–Barr virus
SubjectLMP-1 oncogene
Subjectblood donors
Subjectseroprevalence
Subjecttransfusion
Subjectviremia
TitleEpstein-Barr Virus Epidemiology, Serology, and Genetic Variability of LMP-1 Oncogene Among Healthy Population: An Update.
TypeArticle
Pagination1-16
Volume Number8
dc.identifier.essn 2234-943X


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