• Claudin-1, A Double-Edged Sword in Cancer. 

      Bhat, Ajaz A; Syed, Najeeb; Therachiyil, Lubna; Nisar, Sabah; Hashem, Sheema; ... more authors ( MDPI , 2020 , Article Review)
      Claudins, a group of membrane proteins involved in the formation of tight junctions, are mainly found in endothelial or epithelial cells. These proteins have attracted much attention in recent years and have been implicated ...
    • Cytokine- and chemokine-induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy 

      Bhat, Ajaz A.; Nisar, Sabah; Singh, Mayank; Ashraf, Bazella; Masoodi, Tariq; ... more authors ( Wiley , 2022 , Article Review)
      Colorectal cancer (CRC) is a predominant life-threatening cancer, with liver and peritoneal metastases as the primary causes of death. Intestinal inflammation, a known CRC risk factor, nurtures a local inflammatory environment ...
    • Decoding the functional role of extracellular vesicles in hepatocellular carcinoma: implications in clinical theranostics 

      Kalyani, Patil; Dermime, Said; Uddin, Shahab ( Elsevier , 2022 , Book chapter)
      Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer in adults, the sixth most commonly diagnosed neoplasia, and the third leading cause of cancer-related deaths worldwide. Despite tangible ...
    • Exploring Dysregulated Signaling Pathways in Cancer. 

      Nisar, Sabah; Hashem, Sheema; Yadav, Santosh K; Muralitharan, Sankavi; Therachiyil, Lubna; ... more authors ( Bentham Science Publishers , 2020 , Article Review)
      Cancer cell biology takes advantage of identifying diverse cellular signaling pathways that are disrupted in cancer. Signaling pathways are an important means of communication from the exterior of cell to intracellular ...
    • Tight Junction Proteins and Signaling Pathways in Cancer and Inflammation: A Functional Crosstalk. 

      Bhat, Ajaz A; Uppada, Srijayaprakash; Achkar, Iman W; Hashem, Sheema; Yadav, Santosh K; ... more authors ( Frontiers Media , 2019 , Article)
      The ability of epithelial cells to organize through cell-cell adhesion into a functioning epithelium serves the purpose of a tight epithelial protective barrier. Contacts between adjacent cells are made up of tight junctions ...