Browsing by Author "Zaravinos, Apostolos"
Now showing items 1-17 of 17
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Clinical significance of P-class pumps in cancer (Review)
Themistocleous, Sophia C.; Yiallouris, Andreas; Tsioutis, Constantinos; Zaravinos, Apostolos; Johnson, Elizabeth O.; Patrikios, Ioannis... more authors ... less authors ( Spandidos Publications , 2021 , Article)P-class pumps are specific ion transporters involved in maintaining intracellular/extracellular ion homeostasis, gene transcription, and cell proliferation and migration in all eukaryotic cells. The present review aimed ... -
DEFECTIVE NATURAL KILLER CELLS IN MELANOMA: ROLE OF NKG2D IN THE PATHOGENESIS AND IMMUNOTHERAPY
Bonavida, Benjamin; Touboul, Roni; Zaravinos, Apostolos ( Begell House , 2021 , Article)Melanoma is the most aggressive and deadliest form of skin cancer, and its prognosis is very poor. While the early detection is responsive to many treatments, metastatic melanoma is refractory to most of them. In the USA, ... -
Distinct genomic features across cytolytic subgroups in skin melanoma.
Roufas, Constantinos; Georgakopoulos-Soares, Ilias; Zaravinos, Apostolos ( Springer , 2021 , Article)Skin melanoma is a highly immunogenic cancer. The intratumoral immune cytolytic activity (CYT) reflects the ability of cytotoxic T and NK cells to eliminate cancer cells, and is associated with improved patient survival. ... -
Erratum: Author Correction: Signatures of co-deregulated genes and their transcriptional regulators in colorectal cancer (NPJ systems biology and applications (2020) 6 1 (23))
Mastrogamvraki, Natalia; Zaravinos, Apostolos ( NLM (Medline) , 2020 , Other)In the original version of this Article, the wrong images were supplied for Figures 7 and 10. This has now been corrected in both the HTML and PDF versions of the Article. -
Gravitational Influence on Human Living Systems and the Evolution of Species on Earth
Adamopoulos, Konstantinos; Koutsouris, Dimitrios; Zaravinos, Apostolos; Lambrou, George I. ( MDPI , 2021 , Article Review)Gravity constituted the only constant environmental parameter, during the evolutionary period of living matter on Earth. However, whether gravity has affected the evolution of species, and its impact is still ongoing. The ... -
High expression of immune checkpoints is associated with the TIL load, mutation rate and patient survival in colorectal cancer.
Kitsou, Mara; Ayiomamitis, Georgios D; Zaravinos, Apostolos ( Spandidos Publications , 2020 , Article)Adoptive cell therapy with the use of tumor-infiltrating lymphocytes (TILs) is a very promising immunotherapeutic approach for the treatment of patients with colorectal cancer (CRC). However, within the tumor microenvironment, ... -
Human papillomavirus E7 binds Oct4 and regulates its activity in HPV-associated cervical cancers.
Panayiotou, Theofano; Michael, Stella; Zaravinos, Apostolos; Demirag, Ece; Achilleos, Charis; Strati, Katerina... more authors ... less authors ( Public Library of Science , 2020 , Article)Octamer binding transcription factor-4 (Oct4), is highly expressed in stem cells and has indispensable roles in pluripotency and cellular reprogramming. In contrast to other factors used for cellular reprogramming, a role ... -
Identification of Co-Deregulated Genes in Urinary Bladder Cancer Using High-Throughput Methodologies
Lambrou, George I.; Vichos, Kleanthis; Koutsouris, Dimitrios; Zaravinos, Apostolos ( MDPI , 2021 , Article)Urinary bladder cancer (UBC) is the second most common urogenital solid tumor and the eleventh in the rank among all types of solid tumors. Although several oncogenes and tumor suppressors are known to be implicated in the ... -
ILK silencing inhibits migration and invasion of more invasive glioblastoma cells by downregulating ROCK1 and Fascin-1.
Louca, Maria; Zaravinos, Apostolos; Stylianopoulos, Triantafyllos; Gkretsi, Vasiliki ( Springer , 2020 , Article)Glioblastoma multiforme (GBM) is the most aggressive type of brain tumor and it is associated with poor survival. Integrin-linked kinase (ILK) is a serine/threonine protein pseudo-kinase that binds to the cytoplasmic domains ... -
Information, Thermodynamics and Life: A Narrative Review
Lambrou, George I.; Zaravinos, Apostolos; Ioannidou, Penelope; Koutsouris, Dimitrios ( MDPI , 2021 , Article Review)Information is probably one of the most difficult physical quantities to comprehend. This applies not only to the very definition of information, but also to the physical entity of information, meaning how can it be ... -
Molecular correlates of immune cytolytic subgroups in colorectal cancer by integrated genomics analysis
Roufas, Constantinos; Georgakopoulos-Soares, Ilias; Zaravinos, Apostolos ( Oxford University Press , 2021 , Article)Although immune checkpoint inhibition (ICI) has shown promising results in metastatic dMMR/MSI-H colorectal cancer (CRC), the majority of pMMR/MSS patients do not respond to such therapies. To systematically evaluate the ... -
New clinical approaches and emerging evidence on immune-checkpoint inhibitors as anti-cancer therapeutics: CTLA-4 and PD-1 pathways and beyond
Christodoulou, Maria-Ioanna; Zaravinos, Apostolos ( Begell House Inc. , 2019 , Article)The development of immune checkpoint blockers, primarily comprising the anti-PD-1/anti-PD-L1 and anti-CTLA-4 monoclonal antibodies, has formed the therapeutic landscape of quite a few different cancer types. In spite of ... -
The Non-Coding RNA and Its Role in Tumor Therapy-Induced Resistance.
Lambrou, George I; Hatziagapiou, Kyriaki; Zaravinos, Apostolos ( MDPI , 2020 , Article)The growth arrest-specific transcript 5 () is a >200-nt lncRNA molecule that regulates several cellular functions, including proliferation, apoptosis, invasion and metastasis, across different types of human cancers. Here, ... -
Regulation of NKG2D by RKIP: Implications on NK-mediated cytotoxicity and cytokine production
Galal, Youssef; Zaravinos, Apostolos; Bonavida, Benjamin ( Elsevier , 2021 , Book chapter)RKIP (Raf kinase inhibitory protein) is a metastatic suppressor and a chemo-immuno-sensitizer. The deficiency or loss of RKIP has been linked with different cancer types, resulting in the activation of the MAPK pathway, ... -
RKIP in human diseases and its potential as a prognostic indicator and therapeutic target
Christofi, Theodoulakis; Zaravinos, Apostolos ( Elsevier , 2020 , Book chapter)The Raf kinase inhibitory protein (RKIP) is an inhibitor of the RAF/MEK/ERK and NF-κB signaling pathways, through which it regulates several key processes of the cell's physiology, such as its proliferation, motility and ... -
Signatures of co-deregulated genes and their transcriptional regulators in colorectal cancer.
Mastrogamvraki, Natalia; Zaravinos, Apostolos ( Nature Research , 2020 , Article)The deregulated genes in colorectal cancer (CRC) vary significantly across different studies. Thus, a systems biology approach is needed to identify the co-deregulated genes (co-DEGs), explore their molecular networks, and ... -
Silencing of Growth Differentiation Factor-15 Promotes Breast Cancer Cell Invasion by Down-regulating Focal Adhesion Genes.
Zaravinos, Apostolos; Gkretsi, Vasiliki; Andreas, Stylianou; Maria, Kalli; Maria, Louca; Chrysovalantis, Voutouri; Triantafyllos, Stylianopoulos... more authors ... less authors ( International Institute of Anticancer Research , 2020 , Article)As metastasis accounts for most breast cancer (BC)-related deaths, identifying key players becomes research priority. Growth differentiation factor-15 (GDF15), a member of the transforming growth factor-β superfamily, is ...