Browsing by Author "Wheatley, Adam K"

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    • Author Correction: Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses. 

      Kanekiyo, Masaru; Joyce, M Gordon; Gillespie, Rebecca A; Gallagher, John R; Andrews, Sarah F; ... more authors ( Nature Research , 2019 , Article)
      In the version of this article initially published, the labels (50 Å) above the scale bars in Fig. 1b were incorrect. The correct size is 50 nm. The error has been corrected in the HTML and PDF versions of the article.

    • Design of Nanoparticulate Group 2 Influenza Virus Hemagglutinin Stem Antigens That Activate Unmutated Ancestor B Cell Receptors of Broadly Neutralizing Antibody Lineages. 

      Corbett, Kizzmekia S; Moin, Syed M; Yassine, Hadi M; Cagigi, Alberto; Kanekiyo, Masaru; ... more authors ( American Society for Microbiology , 2019 , Article)
      Influenza vaccines targeting the highly conserved stem of the hemagglutinin (HA) surface glycoprotein have the potential to protect against pandemic and drifted seasonal influenza viruses not covered by current vaccines. ...

    • Immunomodulation Induced by Host Pathogen Interaction 

      Yassine, Hadi M.; Moin, Syed M.; Cyprian, Farhan S.; Wheatley, Adam K.; Nasrallah, Gheyath K. ( Hindawi , 2019 , Article)
      Controlling and preventing infections require deep understanding of the complex interplay that occurs between the host and pathogen following infection. In essence, immunomodulation is any process leading to an immune ...

    • Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses. 

      Kanekiyo, Masaru; Joyce, M Gordon; Gillespie, Rebecca A; Gallagher, John R; Andrews, Sarah F; ... more authors ( Nature Research , 2019 , Article)
      The present vaccine against influenza virus has the inevitable risk of antigenic discordance between the vaccine and the circulating strains, which diminishes vaccine efficacy. This necessitates new approaches that provide ...

    • Reconstituted B cell receptor signaling reveals carbohydrate-dependent mode of activation 

      Villar, Rina F.; Patel, Jinal; Weaver, Grant C.; Kanekiyo, Masaru; Wheatley, Adam K.; ... more authors ( Nature Publishing Group , 2016 , Article)
      Activation of immune cells (but not B cells) with lectins is widely known. We used the structurally defined interaction between influenza hemagglutinin (HA) and its cell surface receptor sialic acid (SA) to identify a B ...

    • Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses 

      Joyce, M. Gordon; Wheatley, Adam K.; Thomas, Paul V.; Chuang, Gwo-Yu; Soto, Cinque; ... more authors ( Elsevier Inc. , 2016 , Article)
      Antibodies capable of neutralizing divergent influenza A viruses could form the basis of a universal vaccine. Here, from subjects enrolled in an H5N1 DNA/MIV-prime-boost influenza vaccine trial, we sorted hemagglutinin ...