Browsing by Author "Zupin, Luisa"
Now showing items 1-20 of 32
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Advanced photodynamic therapy with an engineered M13 phage targeting EGFR: Mitochondrial localization and autophagy induction in ovarian cancer cell lines
Barbara, Bortot; Apollonio, Maura; Baj, Gabriele; Andolfi, Laura; Zupin, Luisa; Crovella, Sergio; di Giosia, Matteo; Cantelli, Andrea; Saporetti, Roberto; Ulfo, Luca; Petrosino, Annapaola; Di Lorenzo, Giovanni; Romano, Federico; Ricci, Giuseppe; Mongiat, Maurizio; Danielli, Alberto; Calvaresi, Matteo; Biffi, Stefania... more authors ... less authors ( Elsevier , 2022 , Article)Photodynamic therapy (PDT) is a potential synergistic approach to chemotherapy for treating ovarian cancer, the most lethal gynecologic malignancy. Here we used M13 bacteriophage as a targeted vector for the efficient ... -
Bioactive Antimicrobial Peptides: A New Weapon to Counteract Zoonosis.
Zupin, Luisa; Santos-Silva, Carlos André Dos; Al Mughrbi, Aya R Hamad; Vilela, Livia Maria Batista; Benko-Iseppon, Ana Maria; Crovella, Sergio... more authors ... less authors ( MDPI , 2022 , Article Review)Zoonoses have recently become the center of attention of the general population and scientific community. Notably, more than 30 new human pathogens have been identified in the last 30 years, 75% of which can be classified ... -
Blue Laser Light Counteracts HSV-1 in the SH-SY5Y Neuronal Cell Model of Infection
Zupin, Luisa; Crovella, Sergio ( MDPI , 2022 , Other)Herpes simplex virus 1 (HSV-1) is wide-spread virus that triggers painful and recurrent infections, as herpes labialis, causing blister lesions on the lip. HSV-1 infection can be a lifelong condition starting from childhood ... -
Blue photobiomodulation LED therapy impacts SARS-CoV-2 by limiting its replication in Vero cells
Zupin, L.; Zupin, Luisa; Gratton, Rossella; Fontana, Francesco; Clemente, Libera; Pascolo, Lorella; Ruscio, Maurizio; Crovella, Sergio... more authors ... less authors ( Wiley , 2021 , Other)The study of any intervention able to counteract SARS-CoV-2 pandemic is considerably envisaged. It was previously shown, in in vitro models of infections, that the LED blue light is able to decrease the viral load of HSV-1 ... -
Clinical–Epidemiological Characteristics and IFITM-3 (rs12252) Variant Involvement in HIV-1 Mother-to-Children Transmission Susceptibility in a Brazilian Population
Leandro, Dalila Bernardes; Celerino da Silva, Ronaldo; Rodrigues, Jessyca Kalynne Farias; Leite, Maria Carollayne Gonçalves; Arraes, Luiz Claudio; Coelho, Antonio Victor Campos; Crovella, Sergio; Zupin, Luisa; Guimarães, Rafael Lima... more authors ... less authors ( MDPI , 2023 , Article)Mother-to-children transmission (MTCT) is the main infection route for HIV-1 in children, and may occur during pregnancy, delivery, and/or postpartum. It is a multifactorial phenomenon, where genetic variants play an ... -
Comparison between nucleic acid amplification tests, antigen immunofluorescence assay, and in vitro infectivity in SARS-CoV-2 diagnosis.
Zupin, Luisa; Fontana, Francesco; Clemente, Libera; Ruscio, Maurizio; Crovella, Sergio ( Springer , 2022 , Article)The number of SARS-CoV-2 detection tests requested to the laboratories has dramatically increased together with an urgent need to release reliable responses in a very short time. The two options taken into consideration ... -
Direct inactivation of SARS-CoV-2 by low level blue photobiomodulation LED at 470, 454 and 450 nm.
Zupin, Luisa; Gratton, Rossella; Milani, Margherita; Clemente, Libera; Fontana, Francesco; Ruscio, Maurizio; Crovella, Sergio... more authors ... less authors ( Wiley , 2022 , Article)Blue light has been already reported as able to counteract different types of microorganisms including Gram-positive and Gram-negative bacteria, fungi and viruses, especially the enveloped ones. It has been reported that ... -
Effect of near-infrared and blue laser light on vero E6 cells SARS-CoV-2 infection model
Zupin, Luisa; Clemente, Libera; Fontana, Francesco; Crovella, Sergio ( Wiley , 2022 , Other)Photobiomodulation therapy (PBMT) employing laser light has been emerging as a safe strategy to challenge viruses. In this study the effect of blue and near-infrared (NIR) laser light was assessed in an in vitro model of ... -
Effect of Short Time of SARS-CoV-2 Infection in Caco-2 Cells.
Zupin, Luisa; Fontana, Francesco; Clemente, Libera; Ruscio, Maurizio; Ricci, Giuseppe; Crovella, Sergio... more authors ... less authors ( MDPI , 2022 , Article)Coronavirus disease 19 (COVID-19) clinical manifestations include the involvement of the gastrointestinal tract, affecting around 10% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected children. In ... -
Evaluation of residual infectivity after SARS-CoV-2 aerosol transmission in a controlled laboratory setting
Zupin, Luisa; Licen, Sabina; Milani, Margherita; Clemente, Libera; Martello, Lorenzo; Semeraro, Sabrina; Fontana, Francesco; Ruscio, Maurizio; Miani, Alessandro; Crovella, Sergio; Barbieri, Pierluigi... more authors ... less authors ( MDPI , 2021 , Article)Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is mainly transmitted through respiratory droplets, aerosols, or direct contact with fomites from an infected subject. It has been reported that SARS-CoV-2 ... -
FTIR Spectroscopy to Reveal Lipid and Protein Changes Induced on Sperm by Capacitation: Bases for an Improvement of Sample Selection in ART.
Pachetti, Maria; Zupin, Luisa; Venturin, Irene; Mitri, Elisa; Boscolo, Rita; D'Amico, Francesco; Vaccari, Lisa; Crovella, Sergio; Ricci, Giuseppe; Pascolo, Lorella... more authors ... less authors (2020 , Article)Although being a crucial step for Assisted Reproduction Technologies (ART) success, to date sperm selection is based only on morphology, motility and concentration characteristics. Considering the many possible alterations, ... -
Human Defensins from Antivirals to Vaccine Adjuvants: Rediscovery of the Innate Immunity Arsenal
Zupin, Luisa; Crovella, Sergio ( Bentham Science Publishers , 2022 , Other)Human defensins are a class of antimicrobial peptides, belonging to the innate immunity system. These peptides are expressed at the level of respiratory tract (both upper and lower) where they represent the first line of ... -
Impact of Sample Preparation Methods on Single-Cell X-ray Microscopy and Light Elemental Analysis Evaluated by Combined Low Energy X-ray Fluorescence, STXM and AFM
Merolle, Lucia; Pascolo, Lorella; Zupin, Luisa; Parisse, Pietro; Bonanni, Valentina; Gariani, Gianluca; Kenig, Sasa; Bedolla, Diana E.; Crovella, Sergio; Ricci, Giuseppe; Iotti, Stefano; Malucelli, Emil; Kourousias, George; Gianoncelli, Alessandra... more authors ... less authors ( MDPI , 2023 , Article)BACKGROUND: Although X-ray fluorescence microscopy is becoming a widely used technique for single-cell analysis, sample preparation for this microscopy remains one of the main challenges in obtaining optimal conditions for ... -
In vitro effects of photobiomodulation therapy on 50B11 sensory neurons: evaluation of cell metabolism, oxidative stress, mitochondrial membrane potential (MMP), and capsaicin-induced calcium flow
Zupin, Luisa; Barbi, Egidio; Sagredini, Raffaella; Ottaviani, Giulia; Crovella, Sergio; Celsi, Fulvio... more authors ... less authors ( Wiley , 2021 , Article)The analgesic properties of photobiomodulation therapy (PBMT) have been raising increasing interest in the clinical community due to the positive effects observed on patients, nevertheless the mechanistic basis of its ... -
The mitochondrial-related effect of the 905 nm photobiomodulation therapy on 50B11 sensory neurons
Zupin, Luisa; Crovella, Sergio; Milena, Cadenaro; Barbi, Egidio; Celsi, Fulvio ( Wiley , 2023 , Article)Photobiomodulation therapy (PBMT) is known as a complementary tool to alleviate pain sensation in patients, nevertheless, there is still a gap of knowledge on its mechanism of action, thus limiting its clinical employment. ... -
Molecular detection of SARS-CoV-2 from indoor air samples in environmental monitoring needs adequate temporal coverage and infectivity assessment
Pierluigi, Barbieri; Zupin, Luisa; Licen, Sabina; Torboli, Valentina; Semeraro, Sabrina; Cozzutto, Sergio; Palmisani, Jolanda; Di Gilio, Alessia; de Gennaro, Gianluigi; Fontana, Francesco; Omiciuolo, Cinzia; Pallavicini, Alberto; Ruscio, Maurizio; Crovella, Sergio... more authors ... less authors ( Elsevier , 2021 , Article)The relevance of airborne exposure to SARS-CoV-2 in indoor environments is a matter of research and debate, with special importance for healthcare low-risk settings. Experimental approaches to the bioaerosol sampling are ... -
Multiomics integration in skin diseases with alterations in notch signaling pathway: PlatOMICs phase 1 deployment
Brandão, Lucas André Cavalcanti; Tricarico, Paola Maura; Gratton, Rossella; Agrelli, Almerinda; Zupin, Luisa; Abou-Saleh, Haissam; Moura, Ronald; Crovella, Sergio... more authors ... less authors ( MDPI , 2021 , Article Review)The high volume of information produced in the age of omics was and still is an important step to understanding several pathological processes, providing the enlightenment of complex molecular networks and the identification ... -
Nanomedicine as a Potential Tool against Monkeypox.
Mohamed, Nura Adam; Zupin, Luisa; Mazi, Sarah Ismail; Al-Khatib, Hebah A; Crovella, Sergio ( MDPI , 2023 , Article Review)Human monkeypox is a rare viral zoonosis that was first identified in 1970; since then, this infectious disease has been marked as endemic in central and western Africa. The disease has always been considered rare and ... -
Optimization of Anti-SARS-CoV-2 Treatments Based on Curcumin, Used Alone or Employed as a Photosensitizer.
Zupin, Luisa; Fontana, Francesco; Clemente, Libera; Borelli, Violetta; Ricci, Giuseppe; Ruscio, Maurizio; Crovella, Sergio... more authors ... less authors ( MDPI , 2022 , Article)Curcumin, the bioactive compound of the spice , has already been reported as a potential COVID-19 adjuvant treatment due to its immunomodulatory and anti-inflammatory properties. In this study, SARS-CoV-2 was challenged ... -
Paraviral cutaneous manifestations associated to SARS-CoV-2 Omicron variant
Zupin, Luisa; Moltrasio, Chiara; Tricarico, Paola Maura; Del Vecchio, Cecilia; Fontana, Francesco; Marzano, Angelo Valerio; Crovella, Sergio... more authors ... less authors ( Taylor and Francis Group , 2022 , Article)Background: The spreading of the SARS-CoV-2 Omicron variant is probably due to its increased transmissibility and ability to escape from neutralising antibodies. Cutaneous manifestations have been reported after infection ...