Browsing by Author "Mraiche F."
Now showing items 1-9 of 9
-
Cisplatin based therapy: The role of the mitogen activated protein kinase signaling pathway
Achkar I.W.; Abdulrahman N.; Al-Sulaiti H.; Joseph J.M.; Uddin S.; Mraiche F.... more authors ... less authors ( BioMed Central Ltd. , 2018 , Article Review)Cisplatin is a widely used chemotherapeutic agent for treatment of various cancers. However, treatment with cisplatin is associated with drug resistance and several adverse side effects such as nephrotoxicity, reduced ... -
Curcumin-mediated degradation of S-phase kinase protein 2 induces cytotoxic effects in human papillomavirus-positive and negative squamous carcinoma cells
Khan A.Q.; Siveen K.S.; Prabhu K.S.; Kuttikrishnan S.; Akhtar S.; Shaar A.; Raza A.; Mraiche F.; Dermime S.; Uddin S.... more authors ... less authors ( Frontiers Media S.A. , 2018 , Article)S-phase kinase-associated protein2 (Skp2), a proto-oncoprotein, plays an important role in development and progression of human malignancies. Skp2 is frequently overexpressed in many human malignancies. It targets cell ... -
Gelatin-methacryloyl hydrogel based in vitro blood–brain barrier model for studying breast cancer-associated brain metastasis
Augustine, Robin; Zahid, Alap Ali; Mraiche, Fatima; Alam, Khurshid; Al Moustafa, Ala-Eddin; Hasan, Anwarul... more authors ... less authors ( Taylor and Francis Ltd. , 2021 , Article)Breast cancer is one of the leading causes of brain metastasis. Metastasis to the brain occurs if cancer cells manage to traverse the ‘blood-brain barrier’ (BBB), which is a barrier with a very tight junction (TJ) of ... -
Gold Nanoparticle-Based Platforms for Diagnosis and Treatment of Myocardial Infarction
Khan S.; Hasan, Anwarul; Attar F.; Sharifi M.; Siddique R.; Mraiche F.; Falahati M.... more authors ... less authors ( American Chemical Society , 2020 , Article)In recent years, an increasing rate of mortality due to myocardial infarction (MI) has led to the development of nanobased platforms, especially gold nanoparticles (AuNPs), as promising nanomaterials for diagnosis and ... -
Increased complications of COVID-19 in people with cardiovascular disease: Role of the renin-angiotensin-aldosterone system (RAAS) dysregulation
Augustine R.; S A.; Nayeem A.; Salam S.A.; Augustine P.; Dan P.; Maureira P.; Mraiche F.; Gentile C.; Hansbro P.M.; McClements L.; Hasan, Anwarul... more authors ... less authors ( Elsevier Ireland Ltd , 2022 , Article)The rapid spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID?19), has had a dramatic negative impact on public health and economies worldwide. Recent studies ... -
Na + /H + exchanger isoform 1-induced osteopontin expression facilitates cardiac hypertrophy through p90 ribosomal S6 kinase
Abdulrahman N.; Jaspard-Vinassa B.; Fliegel L.; Jabeen A.; Riaz S.; Gadeau A.-P.; Mraiche F.... more authors ... less authors ( NLM (Medline) , 2018 , Article)Cardiovascular diseases are the leading cause of death worldwide. One in three cases of heart failure is due to dilated cardiomyopathy. The Na+/H+ exchanger isoform 1 (NHE1), a multifunctional protein and the key pH regulator ... -
Osteopontin: A Promising Therapeutic Target in Cardiac Fibrosis
Abdelaziz Mohamed I.; Gadeau A.-P.; Hasan, Anwarul; Abdulrahman N.; Mraiche F. ( NLM (Medline) , 2019 , Article)Osteopontin (OPN) is recognized for its significant roles in both physiological and pathological processes. Initially, OPN was recognized as a cytokine with pro-inflammatory actions. More recently, OPN has emerged as a ... -
Overcoming pitfalls: Results from a mandatory peer review process for written examinations
Wilby K.J.; El Hajj M.S.; El-Bashir M.; Mraiche F. ( Elsevier Inc. , 2018 , Article)Problem description: Written assessments are essential components of higher education practices. However, faculty members encounter common pitfalls when designing questions intended to evaluate student-learning outcomes. ... -
Sanguinarine suppresses growth and induces apoptosis in childhood acute lymphoblastic leukemia
Kuttikrishnan S.; Siveen K.S.; Prabhu K.S.; Khan A.Q.; Akhtar S.; Mateo J.M.; Merhi M.; Taha R.; Omri H.E.; Mraiche F.; Dermime S.; Uddin S.... more authors ... less authors ( Taylor and Francis Ltd , 2019 , Article)Sanguinarine (Sang), a plant-derived compound isolated from the roots of Sanguinaria canadensis was evaluated for its potential pro-apoptotic effects in precursor B acute lymphoblastic leukemia (Pre-ALL) cell lines. Treatment ...