Browsing by Author "Abd El-Aleem, Seham A."
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Changes in expression of Kv7.5 and Kv7.2 channels in dorsal root ganglion neurons in the streptozotocin rat model of painful diabetic neuropathy
Laiche, Djouhri; Zeidan, Asad; Abd El-Aleem, Seham A. ( Elsevier , 2020 , Article)Diabetic peripheral neuropathic pain (DPNP), the most debilitating complication of diabetes mellitus, is resistant to current therapy. The pathogenesis of DPNP is still elusive, but several mechanisms have been proposed ... -
Cutaneous Aβ-Non-nociceptive, but Not C-Nociceptive, Dorsal Root Ganglion Neurons Exhibit Spontaneous Activity in the Streptozotocin Rat Model of Painful Diabetic Neuropathy .
Djouhri, Laiche; Zeidan, Asad; Abd El-Aleem, Seham A; Smith, Trevor ( Frontiers Media , 2020 , Article)Diabetic peripheral neuropathic pain (DPNP) is the most devastating complication of diabetes mellitus. Unfortunately, successful therapy for DPNP remains a challenge because its pathogenesis is still elusive. However, DPNP ... -
Follicular dendritic cells
Abd El-Aleem, Seham A; Saber, Entesar Ali; Aziz, Neven M; El-Sherif, Hani; Abdelraof, Asmaa M; Djouhri, Laiche... more authors ... less authors ( Wiley , 2021 , Article Review)Follicular dendritic cells (FDCs) are unique accessory immune cells that contribute to the regulation of humoral immunity. They are multitasker cells essential for the organization and maintenance of the lymphoid architecture, ... -
L5 Spinal Nerve Axotomy Induces Distinct Electrophysiological Changes in Axotomized L5- and Adjacent L4-Dorsal Root Ganglion Neurons in Rats .
Djouhri, Laiche; Zeidan, Asad; Alzoghaibi, Mohammad; Al Otaibi, Mohammad F; Abd El-Aleem, Seham A ( Mary Ann Liebert , 2020 , Article)Peripheral neuropathic pain (PNP) is a major health problem for which effective drug treatment is lacking. Its underlying neuronal mechanisms are still illusive, but pre-clinical studies using animal models of PNP including ... -
Mutual inter-regulation between iNOS and TGF-β1: Possible molecular and cellular mechanisms of iNOS in wound healing.
Abd El-Aleem, Seham A; Mohammed, Hanaa Hassanein; Saber, Entesar Ali; Embaby, Azza S; Djouhri, Laiche ( Elsevier , 2020 , Article)Abnormal wound healing with excessive scarring is a major health problem with socioeconomic and psychological impacts. In human, chronic wounds and scarring are associated with upregulation of the inducible nitric oxide ... -
A possible role for inducible arginase isoform (AI) in the pathogenesis of chronic venous leg ulcer
Abd El-Aleem, Seham A.; Abd-Elghany, Manal Ismail; Ali Saber, Entesar; Jude, Edward B.; Djouhri, Laiche ( Wiley , 2020 , Article)Chronic venous ulcer (CVU) is a major cause of chronic wounds of lower extremities and presents a significant financial and resource burden to health care systems worldwide. Defects in the vasculature, matrix deposition, ...