Browsing by Author "Eid A.H."
Now showing items 1-10 of 10
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7-O-methylpunctatin, a novel homoisoflavonoid, inhibits phenotypic switch of human arteriolar smooth muscle cells
Fardoun M.; Iratni R.; Dehaini H.; Eid A.; Ghaddar T.; El-Elimat T.; Alali F.; Badran A.; Eid A.H.; Baydoun E.... more authors ... less authors ( MDPI AG , 2019 , Article)Remodeling of arterioles is a pivotal event in the manifestation of many inflammation-based cardio-vasculopathologies, such as hypertension. During these remodeling events, vascular smooth muscle cells (VSMCs) switch from ... -
A potential link between oxidative stress and endothelial-to-mesenchymal transition in systemic sclerosis
Thuan,Duong Thi Bich; Zayed,Hatem; Eid,Ali H.; Abou-Saleh,Haissam; Nasrallah,Gheyath K.; Mangoni,Arduino A.; Pintus,Gianfranco... more authors ... less authors ( Frontiers Media S.A. , 2018 , Article Review)Systemic sclerosis (SSc), an autoimmune disease that is associated with a number of genetic and environmental risk factors, is characterized by progressive fibrosis and microvasculature damage in the skin, lungs, heart, ... -
Amelioration of perivascular adipose inflammation reverses vascular dysfunction in a model of nonobese prediabetic metabolic challenge: potential role of antidiabetic drugs
Elkhatib M.A.W.; Mroueh A.; Rafeh R.W.; Sleiman F.; Fouad H.; Saad E.I.; Fouda M.A.; Elgaddar O.; Issa K.; Eid A.H.; Eid A.A.; Abd-Elrahman K.S.; El-Yazbi A.F.... more authors ... less authors ( Mosby Inc. , 2019 , Article)The onset of vascular impairment precedes that of diagnostic hyperglycemia in diabetic patients suggesting a vascular insult early in the course of metabolic dysfunction without a well-defined mechanism. Mounting evidence ... -
Estrogen in vascular smooth muscle cells: A friend or a foe?
DehainiH.; FardounM.; Abou-SalehH.; El-YazbiA.; EidA.A.; EidA.H.... more authors ... less authors ( Elsevier Inc. , 2018 , Article Review)Cardiovascular disease (CVD) continues to be the leading cause of death worldwide. The effect of estrogen on these diseases has been assessed in in vitro and in vivo models, as well as in observational studies. Collectively, ... -
Evaluation of Apoptotic, Antiproliferative, and Antimigratory Activity of Origanum syriacum against Metastatic Colon Cancer Cells
Aldisi S.S.; Jaganjac M.; Eid A.H.; Goktepe I. ( Taylor and Francis Inc. , 2019 , Article)The effect of an ethanolic extract of fresh leaves of Origanum syriacum (OSEE) on the proliferative, apoptotic, and migratory capacities of LoVo and SW620 colon cancer cells was investigated. OSEE showed a concentration-dependent ... -
Impaired cross-talk between NO and hyperpolarization in myoendothelial feedback: a novel therapeutic target in early endothelial dysfunction of metabolic disease
Alaaeddine R.A.; Mroueh A.; Gust S.; Eid A.H.; Plane F.; El-Yazbi A.F.... more authors ... less authors ( Elsevier Ltd , 2019 , Article Review)Over the past three decades, our view of the endothelium rapidly evolved from a static lining of the blood vessels to a dynamic determinant and regulator of vascular tone and homeostasis. It is now widely accepted that ... -
MicroRNAs in Cardiac Hypertrophy
Wehbe N.; Nasser S.A.; Pintus G.; Badran A.; Eid A.H.; Baydoun E.... more authors ... less authors ( MDPI AG , 2019 , Article Review)Like other organs, the heart undergoes normal adaptive remodeling, such as cardiac hypertrophy, with age. This remodeling, however, is intensified under stress and pathological conditions. Cardiac remodeling could be ... -
Naturally-Occurring Bioactives in Oral Cancer: Preclinical and Clinical Studies, Bottlenecks and Future Directions
Butnariu, M.; Quispe, C.; Sharifi-Ra, J.; Pons-Fuste, E.; Lopez-Jorne, P.; Zam, W.; Das, T.; Dey, A.; Kumar, M.; Pentea, M.; Eid, A.H.; Umbetova, A.; Chen, J.-T.... more authors ... less authors ( IMR Press Limited , 2022 , Article)Oral cancer (OC) is the eighth most common cancer, particularly prevalent in developing countries. Current treatment includes a multidisciplinary approach, involving chemo, radio, and immunotherapy and surgery, which depends ... -
Novel therapeutic strategies for spinal osteosarcomas
M. Akhtar, Anwar; El-Baba, Chirine; Elnaggar, Muhammed H.; Elkholy, Yasmeen O.; Mottawea, Mohamed; Johar, Dina; Al Shehabi, Tuqa S.; Kobeissy, Firas; Moussalem, Charbel; Massaad, Elie; Omeis, Ibrahim; Darwiche, Nadine; Eid, A.H.... more authors ... less authors ( Elsevier , 2020 , Article Review)At the dawn of the third millennium, cancer has become the bane of twenty-first century man, and remains a predominant public health burden, affecting welfare and life expectancy globally. Spinal osteogenic sarcoma, a ... -
Unmasking the interplay between mTOR and Nox4: novel insights into the mechanism connecting diabetes and cancer
Mroueh F.M.; Noureldein M.; Zeidan Y.H.; Boutary S.; Irani S.A.M.; Eid S.; Haddad M.; Barakat R.; Harb F.; Costantine J.; Kanj R.; Sauleau E.-A.; Ouhtit A.; Azar S.T.; Eid A.H.; Eid A.A.... more authors ... less authors ( NLM (Medline) , 2019 , Article)Cancer was recently annexed to diabetic complications. Furthermore, recent studies suggest that cancer can increase the risk of diabetes. Consequently, diabetes and cancer share many risk factors, but the cellular and ...