Browsing by Author "Elkhalifa, Dana"
Now showing items 1-7 of 7
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A comprehensive review on the antiviral activities of chalcones
Elkhalifa, Dana; Al-Hashimi, Israa; Al Moustafa, Ala-Eddin; Khalil, Ashraf ( Taylor and Francis Ltd. , 2021 , Article)Some viral outbreaks have plagued the world since antiquity, including the most recent COVID-19 pandemic. The continuous spread and emergence of new viral diseases have urged the discovery of novel treatment options that ... -
Characteristics and quality of adverse drug reaction reporting among healthcare providers at Rumailah Hospital in Qatar
Alsalimy, Noor; Magdy, Moammed; Elkhalifa, Dana; Al Shammaa, Aya; Awaisu, Ahmed ( Hamad bin Khalifa University Press (HBKU Press) , 2017 , Article)Introduction: Under-reporting of adverse drug reactions (ADRs) and low-quality reporting are a widespread phenomenon globally.1 There is a need for more insight on the role of pharmacists and other healthcare professionals ... -
Characteristics and quality of adverse drug reaction reporting: a comparison of pharmacists with other healthcare providers at a multi-specialty hospital in Qatar
Alsalimy, Noor; Elkhalifa, Dana; Al Shammaa, Aya; Magdy, Mohamed; Awaisu, Ahmed ( Springer International Publishing , 2017 , Article)Objective: Rumailah Hospital (RH) is a multi-specialty hospital with a capacity of 605 beds that serves subacute and long-term patients in Qatar. Since under-reporting and low-quality reporting of adverse drug reactions ... -
Design, synthesis, and validation of novel nitrogen-based chalcone analogs against triple negative breast cancer
Elkhalifa, Dana; Siddique, Abu Bakar; Qusa, Mohammed; Cyprian, Farhan S.; El Sayed, Khalid; Alali, Feras; Al Moustafa, Ala-Eddin; Khalil, Ashraf... more authors ... less authors ( Elsevier Masson s.r.l. , 2020 , Article)Great strides have been made in triple negative breast cancer (TNBC) treatment, which represents 20% of total predicted annual US breast cancer (BC) cases. Despite the development of several therapeutics, TNBC patients ... -
Novel nitrogen-based chalcone analogs provoke substantial apoptosis in HER2-positive human breast cancer cells via JNK and ERK1/ERK2 signaling pathways
Rizeq, Balsam; Gupta, Ishita; Kheraldine, Hadeel; Elkhalifa, Dana; Al-Farsi, Halema F.; Moustafa, Ala-Eddin A.; Khalil, Ashraf... more authors ... less authors ( MDPI , 2021 , Article)Natural chalcones possess antitumor properties and play a role as inducers of apoptosis, antioxidants and cytotoxic compounds. We recently reported that novel nitrogen chalcone-based compounds, which were generated in our ... -
Novel polymethoxylated chalcones as potential compounds against kras-mutant colorectal cancers
Mahmoud, Alaa; Elkhalifa, Dana; Alali, Feras; Al Moustafa, Ala-Eddin; Khalil, Ashraf ( Bentham Science Publishers , 2020 , Article)Background/Objective: KRAS-mutant colorectal cancers (CRC) are tumors that are associated with poor prognosis. However, no effective treatments are available to target them. Therefore, we designed and synthesized novel ... -
Targeting triple negative breast cancer heterogeneity with chalcones: a molecular insight.
Elkhalifa, Dana; Alali, Feras; Al Moustafa, Ala-Eddin; Khalil, Ashraf ( Informa Healthcare , 2019 , Article Review)Triple negative breast cancers (TNBCs) are aggressive heterogeneous cancers with not yet determined conventional targeted medication. Therefore, identification of new alternatives or improved treatment options to combat ...