تصفح حسب المؤلف "Ahmad, Aamir"
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Analysis of signaling cascades from myeloma cells treated with pristimerin
Almaghrbi, Heba; Elkardawy, Rehab; Kumar. S, Udhaya; Kuttikrishnan, Shilpa; Abunada, Taghreed; Kashyap, Manoj Kumar; Ahmad, Aamir; Uddin, Shahab; Doss. C, George Priya; Zayed, Hatem... more authors ... less authors ( Elsevier , 2022 , Book chapter)Multiple myeloma (MM) is the 2nd most frequently diagnosed blood cancer after non-Hodgkin's lymphoma. The present study aimed to identify the differentially expressed genes (DEGs) between the control and pristimerin-treated ... -
Bioinformatics Analysis Reveals FOXM1/BUB1B Signaling Pathway as a Key Target of Neosetophomone B in Human Leukemic Cells: A Gene Network-Based Microarray Analysis
Kuttikrishnan, Shilpa; Masoodi, Tariq; Sher, Gulab; Bhat, Ajaz A.; Patil, Kalyani; El-Elimat, Tamam; Oberlies, Nicholas H.; Pearce, Cedric J.; Haris, Mohmmad; Ahmad, Aamir; Alali, Feras Q.; Uddin, Shahab... more authors ... less authors ( Frontiers Media S.A. , 2022 , Article)Abnormal expression of Forkhead box protein M1 (FOXM1) and serine/threonine kinase Budding uninhibited by benzimidazoles 1 (BUB1B) contributes to the development and progression of several cancers, including chronic ... -
Cross-talk between the microbiome and chronic inflammation in esophageal cancer: potential driver of oncogenesis
Sharma, Tarang; Gupta, Ashna; Chauhan, Ravi; Bhat, Ajaz A.; Nisar, Sabah; Hashem, Sheema; Akhtar, Sabah; Ahmad, Aamir; Haris, Mohammad; Singh, Mayank; Uddin, Shahab... more authors ... less authors ( Springer , 2022 , Article)Esophageal cancer (EC) is frequently considered a lethal malignancy and is often identified at a later stage. It is one of the major causes of cancer-related deaths globally. The conventional treatment methods like ... -
Epigenetic programing of cancer stemness by transcription factors-non-coding RNAs interactions
Alsayed, Reem Khaled M.E.; Sheikhan, Khalid Sultan A.M.; Alam, Majid Ali; Buddenkotte, Jorg; Steinhoff, Martin; Uddin, Shahab; Ahmad, Aamir... more authors ... less authors ( Elsevier , 2023 , Article Review)Cancer ‘stemness’ is fundamental to cancer existence. It defines the ability of cancer cells to indefinitely perpetuate as well as differentiate. Cancer stem cell populations within a growing tumor also help evade the ... -
Epigenetic regulation of CXCR4 signaling in cancer pathogenesis and progression
Reem Khaled M.E., Alsayed; Khan, Abdul Q.; Ahmad, Fareed; Ansari, Abdul Wahid; Alam, Majid Ali; Buddenkotte, Jorg; Steinhoff, Martin; Uddin, Shahab; Ahmad, Aamir... more authors ... less authors ( Elsevier , 2022 , Article)Signaling involving chemokine receptor CXCR4 and its ligand SDF-1/CXL12 has been investigated for many years for its possible role in cancer progression and pathogenesis. Evidence emerging from clinical studies in recent ... -
Exploring the in vivo anti-cancer potential of Neosetophomone B in leukemic cells using a zebrafish xenograft model
Kuttikrishnan, Shilpa; Hasan, Maram; Prabhu, Kirti S.; El-Elimat, Tamam; Oberlies, Nicholas H.; Pearce, Cedric J.; Alali, Feras Q.; Ahmad, Aamir; Pourkarimi, Ehsan; Bhat, Ajaz A.; Yalcin, Huseyin C.; Uddin, Shahab... more authors ... less authors ( Elsevier Inc. , 2024 , Article)Neosetophomone B (NSP–B) is a unique meroterpenoid fungal secondary metabolite that has previously demonstrated promising anti-cancer properties against various cancer cell lines in vitro. However, its in vivo anti-cancer ... -
Long non-coding RNAs regulated NF-κB signaling in cancer metastasis: Micromanaging by not so small non-coding RNAs
Shaniya, Ahmad; Abbas, Madiha; Ullah, Mohammad Fahad; Aziz, Moammir H.; Beylerli, Ozal; Alam, Majid Ali; Syed, Mansoor Ali; Uddin, Shahab; Ahmad, Aamir... more authors ... less authors ( Elsevier Ltd , 2022 , Article)Cancer metastasis is a major reason for the cancer-associated deaths and a role of long non-coding RNAs (lncRNAs) in cancer metastasis is increasingly being realized. Among the many oncogenic pathways, NF-κB signalling’s ... -
Molecular pathogenesis of Cutaneous T cell Lymphoma: Role of chemokines, cytokines, and dysregulated signaling pathways
Kalyani, Patil; Kuttikrishnan, Shilpa; Khan, Abdul Q.; Ahmad, Fareed; Alam, Majid; Buddenkotte, Joerg; Ahmad, Aamir; Steinhoff, Martin; Uddin, Shahab... more authors ... less authors ( Elsevier , 2022 , Article Review)Cutaneous T cell lymphomas (CTCLs) are a heterogeneous group of lymphoproliferative neoplasms that exhibit a wide spectrum of immune-phenotypical, clinical, and histopathological features. The biology of CTCL is complex ... -
Natural resorcylic acid lactones: A chemical biology approach for anticancer activity
Shilpa, Kuttikrishnan; Prabhu, Kirti S.; Al Sharie, Ahmed H.; Al Zu'bi, Yazan O.; Alali, Feras Q.; Oberlies, Nicholas H.; Ahmad, Aamir; El-Elimat, Tamam; Uddin, Shahab... more authors ... less authors ( Elsevier , 2022 , Article)Resorcylic acid lactones (RALs) are fungal polyketides that consist of a β-resorcylic acid residue (2,4-dihydroxybenzoic acid) embedded in a macrolactone ring. RALs exhibit a broad range of biological activities, including ... -
The plasticity of pancreatic cancer stem cells: implications in therapeutic resistance
Patil, Kalyani; Khan, Farheen B.; Akhtar, Sabah; Ahmad, Aamir; Uddin, Shahab ( Springer Nature , 2021 , Article)The ever-growing perception of cancer stem cells (CSCs) as a plastic state rather than a hardwired defined entity has evolved our understanding of the functional and biological plasticity of these elusive components in ... -
Sanguinarine Induces Apoptosis in Papillary Thyroid Cancer Cells via Generation of Reactive Oxygen Species.
Khan, Abdul Q; Mohamed, Elham A N; Hakeem, Ishrat; Nazeer, Aneeza; Kuttikrishnan, Shilpa; Prabhu, Kirti S; Siveen, Kodappully S; Nawaz, Zafar; Ahmad, Aamir; Zayed, Hatem; Uddin, Shahab... more authors ... less authors ( MDPI , 2020 , Article)Sanguinarine (SNG), a natural compound with an array of pharmacological activities, has promising therapeutic potential against a number of pathological conditions, including malignancies. In the present study, we have ... -
Thiostrepton inhibits growth and induces apoptosis by targeting FoxM1/SKP2/MTH1 axis in B-precursor acute lymphoblastic leukemia cells
Kuttikrishnan, Shilpa; Prabhu, Kirti S.; Khan, Abdul Q.; Alali, Feras Q.; Ahmad, Aamir; Uddin, Shahab... more authors ... less authors ( Taylor and Francis Group , 2021 , Article)Forkhead box M1 (FoxM1) is a transcription factor that plays an important role in the etiology of many cancers, however, its role has not been elucidated in B-precursor acute lymphoblastic leukemia (B-pre-ALL). In the ...