Browsing by Author "Riaz, Sadaf"
Now showing items 1-9 of 9
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Cathepsin B Induced Cardiomyocyte Hypertrophy Requires Activation of the Na+/+ Exchanger Isoform-1
Riaz, Sadaf ( Hamad bin Khalifa University Press (HBKU Press) , 2016 , Conference Paper)Background: Progression of the heart to failure is primarily caused due to significant remodeling of both the extracellular matrix (ECM) and subcellular organelles, a hallmark of cardiac hypertrophy (CH). Uncontrolled ECM ... -
Cathepsin B Induced Cardiomyocyte Hypertrophy Requires Activation of The Na+/H+ Exchanger Isoform-1
Riaz, Sadaf (2016 , Master Thesis)Multiple studies have demonstrated that proteases, specifically cathepsin B (Cat B) and matrix metalloproteinase-9 (MMP-9) contribute to the remodeling of the extracellular matrix (ECM), a hallmark of cardiac hypertrophy ... -
The design and implementation of an undergraduate health professional degree elective course on scientific writing, peer assessment, and critical appraisal
Osman, Aisha; Al-Badriyeh, Daoud; Hussain, Farhat Naz; Riaz, Sadaf; Elewa, Hazem; Mraiche, Fatima... more authors ... less authors ( Elsevier , 2022 , Other)Background and purpose: Strong writing skills are critical to the pharmacy profession. This paper describes the design, delivery, and impact of a course intended to develop pharmacy students' scientific writing, peer ... -
The Efficacy of Etoposide on H9c2 Cardiomyoblasts Against Doxorubicin Induced Cardiotoxicity
Shabana, Sara; Aden, Suad; Abdulrahman, Nabeel; Riaz, Sadaf; Jaballah, Maiy; Mohamed, Iman A.; Mraiche, Fatima... more authors ... less authors ( OMICS International , 2015 , Article)Background: Doxorubicin (DOX), a widely used anticancer drug, has been associated with cardiotoxicity. Recently, DOX-induced cardiotoxicity has been attributed to topoisomerase II (TOPII)-β expression and activity. In our ... -
Inhibition of p90 Ribosomal S6 Kinase Attenuates Cell Migration and Proliferation of the Human Lung Adenocarcinoma through Phospho-GSK-3b and Osteopontin
Abdulrahman, Nabeel; Jaballah, Maiy; Poomakkoth, Noufira; Riaz, Sadaf; Abdelaziz, Somaya; Issa, Aya; Mraiche, Fatima... more authors ... less authors ( Hamad bin Khalifa University Press (HBKU Press) , 2016 , Conference Paper)Background Lung cancer is the second most common cancer in both men and women and it is the leading cause of cancer deaths worldwide. Lung cancer can be divided into two broad categories: non-small cell lung cancer ... -
Inhibition of p90 ribosomal S6 kinase attenuates cell migration and proliferation of the human lung adenocarcinoma through phospho-GSK-3β and osteopontin
Abdulrahman, Nabeel; Jaballah, Maiy; Poomakkoth, Noufira; Riaz, Sadaf; Abdelaziz, Somaia; Issa, Aya; Mraiche, Fatima... more authors ... less authors ( Springer-Verlag , 2016 , Article)p90 ribosomal S6 kinase (p90RSK) constitutes a family of serine/threonine kinases that have been shown to be involved in cell proliferation of various malignancies via direct or indirect effects on the cell-cycle machinery. ... -
Myocardial proteases and cardiac remodeling
Riaz, Sadaf; Zeidan, Asad; Mraiche, Fatima ( Wiley-Liss Inc. , 2017 , Article Review)Cardiac hypertrophy (CH), characterized by the enlargement of cardiomyocytes, fibrosis and apoptosis, is one of the leading causes of death worldwide. Despite the advances in cardiovascular research, there remains a need ... -
The Role of p90 Ribosomal S6 Kinase (RSK) in Tyrosine Kinase Inhibitor (TKI)-Induced Cardiotoxicity
Suleiman, Muna; Al Najjar, Afnan; Zakaria, Zain Z.; Ahmed, Rashid; Yalcin, Huseyin C.; Korashy, Hesham M.; Uddin, Shahab; Riaz, Sadaf; Abdulrahman, Nabeel; Mraiche, Fatima... more authors ... less authors ( Springer , 2023 , Article Review)Targeted therapy, such as tyrosine kinase inhibitors (TKIs), has been approved to manage various cancer types. However, TKI-induced cardiotoxicity is a limiting factor for their use. This issue has raised the need for ... -
The use of Socrative and Yammer online tools to promote interactive learning in pharmacy education
Munusamy, Shankar; Osman, Aisha; Riaz, Sadaf; Ali, Shaima; Mraiche, Fatima ( Elsevier Inc. , 2019 , Article)Background and purpose Engagement of students in the didactic classroom setting restricts students’ time spent towards active learning, which in turn, adversely affects the retention of concepts taught through traditional ...