Browsing by Author "Shanmugakonar, Muralitharan"
Now showing items 1-20 of 20
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Animal Health Monitoring Program (AHMP) of LARC
(2017 , Poster)Animal health monitoring is important to maintain the health of the animals used for research purpose. Maintaining healthy research animals is the prime requisite for best research outcomes. Health monitoring is performed ... -
Cadmium: An Emerging Role in Adipose Tissue Dysfunction
( Springer , 2021 , Article Review)Cadmium (Cd) is a toxic heavy metal that is widespread in the environment due to the substantial anthropogenic inputs from the agriculture and industrial sectors. The toxic impact of Cd adversely affects human health and ... -
Cardiac Myosin Binding Protein-C in Sprague Dawley (SD) Rats exposed to Sub-Chronic oral dose of Cadmium Chloride
( Qatar University Press , 2021 , Poster)Cadmium is one of the major environmental pollutants associated with an increment in industrial and urbanization activities. It has health consequences when it reaches the human diet through the soil, water, and plant. ... -
Chronic Cadmium Exposure Alters Cardiac Matrix Metalloproteinases in the Heart of Sprague-Dawley Rat
( Frontiers Media , 2021 , Article)The aim of this study was to evaluate the role of chronic cadmium exposure in modulating cardiac matrix metalloproteinases (MMPs) in the heart of rats. Adult male Sprague-Dawley rats were exposed to 15 ppm CdCl2 in drinking ... -
Diagnostic Microbiology Laboratory Monitoring of LARC
(2017 , Poster)Microbial free environment of a research facility is critical to maintain animal health. Establishing Microbiological Monitoring Program is mandatory to assure the quality of the system. Microbiological monitoring involves ... -
Early-Life Sugar Consumption Affects the Microbiome in Juvenile Mice
( John Wiley and Sons Inc , 2022 , Article)Scope: The composition of the gut microbiota is influenced by the dietary nutrient. Sugar has been linked with many metabolic health disorders such as heart disease, metabolic syndrome, and immune disorders. Long-term ... -
Effect of CARMA 2sh gene in Mouse embryonic stem (ES) cells
(2017 , Poster)CARMA2 belongs to the CARMA family of proteins. They are involved in the regulation and activation of NF-κB that have a central role in the control of immune and inflammatory response, and cell survival and proliferation. ... -
Environmental Health Monitoring Program (EHMP) of LARC
(2017 , Poster)Routine environmental monitoring is the prime necessity to maintain a Specific Pathogen Free (SPF) facility. Monitoring the animals & its environment is important to control the contamination and outbreak of disease. ... -
Expression of active and inactive forms of CIK and CARMA 2sh proteins in Normal Human Epidermal Keratinocytes (NHEK)
(2016 , Poster)Psoriasis is a debilitating skin disease affecting approximately 23% of human population. The disease is considered to have key genetic underpinning and genome wide association studies and meta analysis have identified ... -
Functional In Vivo Imaging of Tumors.
( Springer , 2020 , Book chapter)Noninvasive imaging of functional and molecular changes in cancer has become an indispensable tool for studying cancer in vivo. Targeting the functional and molecular changes in cancer imaging provides a platform for the ... -
Gut Microbiota and Health: Understanding the Role of Diet
( Qatar University Press , 2020 , Poster)Gut microbiota plays a major role in regulating the host metabolism and immune system. However, the structure of microbiome population is altered constantly by diverse factors including diet and environment. In particular, ... -
Gut Microbiota and Health: Understanding the Role of Diet
( Scientific Research Publishing , 2019 , Article Review)Microbiome now is considered as an organ within our system to regulate metabolism, cellular immune response and eventually maintain the health. Gut microbiota has been studied extensively in the recent past due to the ... -
Gut Microbiota Dysbiosis and Their Impact on Biochemical and Inflammatory Profiles in Cafeteria Diet Fed Sprague Dawley Rats
( Scientific Research Publishing , 2019 , Article)Gut microbiota plays a major role in regulating the host metabolism and immune system. However, the structure of microbiome population is altered constantly by diverse factors including diet and environment. In particular, ... -
Gut Microbiota Dysbiosis in Cafeteria Diet Fed Sprague Dawley Rats
( Scientific Research Publishing , 2018 , Article)Diet plays a major role in the body physiology and metabolism. The quantity, nature and stability of the macronutrients present in the diet have a major impact on the composition of gut microbiota. Gut microbiota plays a ... -
In Vitro Analysis of Psoriasis Linked CARMA2sh Gene in Keratinocytes and Mouse Embryonic Stem Cells towards Developing a Murine Transgenic Model
( American Association For Laboratory Animal Science , 2017 , Poster)Psoriasis is a debilitating skin disease affecting approximately 23% of human population. Genome-wide association studies have identified more than 40 susceptibility loci for psoriasis. CARMA2 proteins play a major role ... -
LABORATORY ANIMAL RESEARCH CENTRE (LARC) “A SPECIFIC PATHOGEN FREE RODENT FACILITY” - COVID – 19 PANDEMIC RESPONSE PLAN
( Qatar University Press , 2020 , Poster)Laboratory Animal Research Centre (LARC) has developed an early emergency operational plan for COVID-19 pandemic situation. Biosafety and biosecurity measures were planned and implemented ahead of time to check the functional ... -
Quantification of bioburden in LARC'S Vivarium
( Qatar University Press , 2020 , Poster)Sanitization of cleanrooms in animal facilities is important as it ensures the level of contamination by different means including personnel activities and failures of HVAC system.Cleanrooms are highly controlled to provide ... -
RAS-mediated oncogenic signaling pathways in human malignancies
( Elsevier , 2018 , Article Review)Abnormally activated RAS proteins are the main oncogenic driver that governs the functioning of major signaling pathways involved in the initiation and development of human malignancies. Mutations in RAS genes and or its ... -
Role of animal research in human malignancies
( Elsevier , 2019 , Book chapter)Animal models are the central backbone in relation to providing the safety information of xenobiotics, the nature of chemicals present in the environment, and understanding the developmental process in disease pathogenesis ... -
Tight Junction Proteins and Signaling Pathways in Cancer and Inflammation: A Functional Crosstalk.
( Frontiers Media , 2019 , Article)The ability of epithelial cells to organize through cell-cell adhesion into a functioning epithelium serves the purpose of a tight epithelial protective barrier. Contacts between adjacent cells are made up of tight junctions ...
