تصفح حسب المؤلف "Kullo, Iftikhar J."

السجلات المعروضة 1 -- 3 من 3

    • Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants 

      Aragam, Krishna G.; Jiang, Tao; Goel, Anuj; Kanoni, Stavroula; Wolford, Brooke N.; ... more authors ( Nature Research , 2022 , Article)
      The discovery of genetic loci associated with complex diseases has outpaced the elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide association study (GWAS) for coronary artery disease (CAD) ...

    • Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis 

      Kanoni, Stavroula; Graham, Sarah E.; Wang, Yuxuan; Surakka, Ida; Ramdas, Shweta; ... more authors ( BioMed Central , 2022 , Article)
      Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding ...

    • A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids 

      Ramdas, Shweta; Judd, Jonathan; Graham, Sarah E.; Kanoni, Stavroula; Wang, Yuxuan; ... more authors ( Elsevier , 2022 , Article)
      A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ...