Browsing by Author "McTamney, Patrick M."
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Reconstituted B cell receptor signaling reveals carbohydrate-dependent mode of activation
Villar, Rina F.; Patel, Jinal; Weaver, Grant C.; Kanekiyo, Masaru; Wheatley, Adam K.; Yassine, Hadi M.; Costello, Catherine E.; Chandler, Kevin B.; McTamney, Patrick M.; Nabel, Gary J.; McDermott, Adrian B.; Mascola, John R.; Carr, Steven A.; Lingwood, Daniel... more authors ... less authors ( Nature Publishing Group , 2016 , Article)Activation of immune cells (but not B cells) with lectins is widely known. We used the structurally defined interaction between influenza hemagglutinin (HA) and its cell surface receptor sialic acid (SA) to identify a B ... -
Use of Hemagglutinin Stem Probes Demonstrate Prevalence of Broadly Reactive Group 1 Influenza Antibodies in Human Sera.
Yassine, Hadi M; McTamney, Patrick M; Boyington, Jeffery C; Ruckwardt, Tracy J; Crank, Michelle C; Smatti, Maria K; Ledgerwood, Julie E; Graham, Barney S... more authors ... less authors ( Nature Publishing Group , 2018 , Article)A better understanding of the seroprevalence and specificity of influenza HA stem-directed broadly neutralizing antibodies (bNAbs) in the human population could significantly inform influenza vaccine design efforts. Here, ...