Browsing by Author "Siva, R."
Now showing items 1-5 of 5
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A comparative computational approach toward pharmacological chaperones (NN-DNJ and ambroxol) on N370S and L444P mutations causing Gaucher's disease.
Thirumal Kumar, D; Iyer, Sharada; Christy, J Priyadharshini; Siva, R; Tayubi, Iftikhar Aslam; George Priya Doss, C; Zayed, Hatem... more authors ... less authors ( Elsevier , 2019 , Book chapter)Gaucher's disease (GD) is the most commonly known lysosomal disorder that occurs due to mutations in the β-glucocerebrosidase (GBA) protein. Our previous findings (Thirumal Kumar, Eldous, Mahgoub, George Priya Doss, Zayed, ... -
Computational and modeling approaches to understand the impact of the Fabry's disease causing mutation (D92Y) on the interaction with pharmacological chaperone 1-deoxygalactonojirimycin (DGJ).
Thirumal Kumar, D; Judith, E; Priyadharshini Christy, J; Siva, R; Tayubi, Iftikhar Aslam; Chakraborty, Chiranjib; George Priya Doss, C; Zayed, Hatem... more authors ... less authors ( Elsevier , 2019 , Book chapter)Fabry's disease (FD) is the second most commonly occurring lysosomal storage disorders (LSDs). The mutations in α-galactosidase A (GLA) protein were widely found to be causative for the Fabry's disease. These mutations ... -
Computational approach to unravel the impact of missense mutations of proteins (D2HGDH and IDH2) causing D-2-hydroxyglutaric aciduria 2.
Thirumal Kumar, D; Jerushah Emerald, L; George Priya Doss, C; Sneha, P; Siva, R; Charles Emmanuel Jebaraj, W; Zayed, Hatem... more authors ... less authors ( Springer US , 2018 , Article)The 2-hydroxyglutaric aciduria (2-HGA) is a rare neurometabolic disorder that leads to the development of brain damage. It is classified into three categories: D-2-HGA, L-2-HGA, and combined D,L-2-HGA. The D-2-HGA includes ... -
Computational insights of K1444N substitution in GAP-related domain of NF1 gene associated with neurofibromatosis type 1 disease: a molecular modeling and dynamics approach
Agrahari A.K.; Muskan M.; George Priya Doss C.; Siva R.; Zayed H. ( Springer New York LLC , 2018 , Article)The NF1 gene encodes for neurofibromin protein, which is ubiquitously expressed, but most highly in the central nervous system. Non-synonymous SNPs (nsSNPs) in the NF1 gene were found to be associated with Neurofibromatosis ... -
Computational structural assessment of BReast CAncer type 1 susceptibility protein (BRCA1) and BRCA1-Associated Ring Domain protein 1 (BARD1) mutations on the protein-protein interface
Thirumal Kumar, D.; Udhaya Kumar, S.; Jain, Nikita; Sowmya, Baviri; Balsekar, Kamakshi; Siva, R.; Kamaraj, Balu; Sidenna, Mariem; George Priya Doss, C.; Zayed, Hatem... more authors ... less authors ( Elsevier , 2022 , Book chapter)Breast cancer type 1 susceptibility protein (BRCA1) is closely related to the BRCA2 (breast cancer type 2 susceptibility protein) and BARD1 (BRCA1-associated RING domain-1) proteins. The homodimers were formed through their ...