Browsing by Author "Youssef, Amal M."
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Novel Quinuclidinone Derivatives Induced Apoptosis in Human Breast Cancer via Targeting P53
Malki, Ahmed; Elbayaa, Rasha Y.; Ali, Omnia; Sultan, Ahmed; Youssef, Amal M. ( Elsevier , 2017 , Article)Small molecules that can target human cancers have been highly sought to increase the anticancer efficacy, the present work describes the design and synthesis of novel series of five quinuclidinone derivatives (2a-2e). ... -
Novel thiosemicarbazides induced apoptosis in human MCF-7 breast cancer cells via JNK signaling
Malki, Ahmed; Elbayaa, Rasha Y.; Ashour, Hayam M.A.; Loffredo, Christopher A.; Youssef, Amal M. ( Taylor & Francis , 2015 , Article)In this study, novel thiosemicarbazides and 1,3,4-oxadiazoles were synthesized and evaluated for their anticancer effects on human MCF-7 breast cancer cell lines. Among the synthesized derivatives studied, compound ...