Browsing by Author "Mraiche, Fatima"
Now showing items 21-40 of 45
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Examining Pharmacy Alumni’s Perceptions of Job Satisfaction, Achievements, and Preparedness: A Mixed-Methods Study
Sara, Elshami; Awaisu, Ahmed; Abidi, Ranin; Al-Ghazal, Lolwa; Al-Hathal, Turfa; Basil, Mounyah; Fakhr, Nour; Yakti, Ola; El-Awaisi, Alla; Stewart, Derek; Mraiche, Fatima; Diab, Mohammad; Mukhalalati, Banan... more authors ... less authors ( Elsevier , 2023 , Article)ObjectivesThere is a scarcity of research that holistically explores pharmacy alumni’s employment experience and their professional performance. Job satisfaction is linked to professionals' productivity and their educational ... -
Glucose and transferrin liganded PLGA nanoparticles internalization in non-small cell lung cancer cells
Benammar, Sarra; Mraiche, Fatima; Mariam Joseph, Jensa; Gorachinova, Katerina ( Qatar University Press , 2020 , Poster)Introduction: Recently, after a decade of confusing results, several studies pointed out that overexpression of GLUT1 (glucose transporter 1) is a biomarker of worse prognosis in NSCLC. Nonetheless, the presence of Transferrin ... -
Heme Oxygenase Isoform 1 Regresses Cardiomyocyte Hypertrophy Through Regressing Sodium Proton Exchanger Isoform 1 Activity
Sobh, Ahmed; Abdulrahman, Nabeel; Bouchoucha, Soumaya; Mraiche, Fatima ( Hamad bin Khalifa University Press (HBKU Press) , 2014 , Conference Paper)Background: Pathological cardiac hypertrophy is a worldwide problem and an independent risk factor that predisposes the heart to failure. Enhanced activity or expression of the sodium proton exchanger isoform 1 (NHE1) has ... -
Identifying the core concepts of pharmacology education: A global initiative
White, Paul J.; Guilding, Clare; Angelo, Tom; Kelly, John P.; Gorman, Laurel; Tucker, Steven J.; Fun, Ashleigh; Han, Jae; Chen, Guanliang; Samak, Yassmin; Babey, Anna Marie; Caetano, Fabiana A.; Sarangi, Sudhir Chandra; Koenig, Jennifer; Hao, Haiping; Goldfarb, Joseph; Karpa, Kelly; Vieira, Luciene; Restini, Carolina; Cunningham, Margaret; Aronsson, Patrik; Kelly-Laubscher, Roisin; Hernandez, Mark; Rangachari, Patangi K.; Mifsud, Janet; Mraiche, Fatima; Sabra, Ramzi; Piñeros, Octavio; Zhen, Xuechu; Kwanashie, Helen; Exintaris, Betty; Karunaratne, Nilushi; Ishii, Kuniaki; Liu, Yannee... more authors ... less authors ( Wiley-Blackwell , 2022 , Article)Background and Purpose: In recent decades, a focus on the most critical and fundamental concepts has proven highly advantageous to students and educators in many science disciplines. Pharmacology, unlike microbiology, ... -
Inhibition of p90 Ribosomal S6 Kinase Attenuates Cell Migration and Proliferation of the Human Lung Adenocarcinoma through Phospho-GSK-3b and Osteopontin
Abdulrahman, Nabeel; Jaballah, Maiy; Poomakkoth, Noufira; Riaz, Sadaf; Abdelaziz, Somaya; Issa, Aya; Mraiche, Fatima... more authors ... less authors ( Hamad bin Khalifa University Press (HBKU Press) , 2016 , Conference Paper)Background Lung cancer is the second most common cancer in both men and women and it is the leading cause of cancer deaths worldwide. Lung cancer can be divided into two broad categories: non-small cell lung cancer ... -
Inhibition of p90 ribosomal S6 kinase attenuates cell migration and proliferation of the human lung adenocarcinoma through phospho-GSK-3β and osteopontin
Abdulrahman, Nabeel; Jaballah, Maiy; Poomakkoth, Noufira; Riaz, Sadaf; Abdelaziz, Somaia; Issa, Aya; Mraiche, Fatima... more authors ... less authors ( Springer-Verlag , 2016 , Article)p90 ribosomal S6 kinase (p90RSK) constitutes a family of serine/threonine kinases that have been shown to be involved in cell proliferation of various malignancies via direct or indirect effects on the cell-cycle machinery. ... -
Inhibition of p90 ribosomal S6 kinase potentiates cisplatin activity in A549 human lung adenocarcinoma cells
Abdulrahman, Nabeel; Siveen, Kodappully Sivaraman; Joseph, Jensa Mariam; Osman, Aisha; Yalcin, Huseyin C.; Hasan, Anwarul; Uddin, Shahab; Mraiche, Fatima... more authors ... less authors ( Wiley , 2020 , Article)© 2020 Royal Pharmaceutical Society Aim: Cisplatin is a standard treatment approach against lung adenocarcinoma. Resistance to cisplatin and the toxic side effects of cisplatin continue to remain a challenge. Combining ... -
Myocardial proteases and cardiac remodeling
Riaz, Sadaf; Zeidan, Asad; Mraiche, Fatima ( Wiley-Liss Inc. , 2017 , Article Review)Cardiac hypertrophy (CH), characterized by the enlargement of cardiomyocytes, fibrosis and apoptosis, is one of the leading causes of death worldwide. Despite the advances in cardiovascular research, there remains a need ... -
Na+/H+ exchanger isoform 1 induced cardiomyocyte hypertrophy involves activation of p90 ribosomal S6 Kinase
Jaballah, Maiy; Mohamed, Iman A.; Alemrayat, Bayan; Al-Sulaiti, Fatima; Mlih, Mohamed; Mraiche, Fatima... more authors ... less authors ( Public Library of Science , 2015 , Article)Studies using pharmacological and genetic approaches have shown that increased activity/expression of the Na+/H+ exchanger isoform 1 (NHE1) play a critical role in the pathogenesis of cardiac hypertrophy. Despite the ... -
Na+/H+ exchanger isoform 1 induced osteopontin expression in cardiomyocytes involves NFAT3/Gata4
Mlih, Mohamed; Abdulrahman, Nabeel; Gadeau, Alain-Pierre; Mohamed, Iman A.; Jaballah, Maiy; Mraiche, Fatima... more authors ... less authors ( Springer-Verlag , 2015 , Article)Osteopontin (OPN), a multifunctional glycophosphoprotein, has been reported to contribute to the development and progression of cardiac remodeling and hypertrophy. Cardiac-specific OPN knockout mice were protected against ... -
Na+/H+ exchanger isoform 1-induced osteopontin expression facilitates cardiomyocyte hypertrophy
Mohamed, Iman A.; Gadeau, Alain-Pierre; Fliegel, Larry; Lopaschuk, Gary; Mlih, Mohamed; Abdulrahman, Nabeel; Fillmore, Natasha; Mraiche, Fatima... more authors ... less authors ( Public Library of Science , 2015 , Article)Enhanced expression and activity of the Na+/H+ exchanger isoform 1 (NHE1) has been implicated in cardiomyocyte hypertrophy in various experimental models. The upregulation of NHE1 was correlated with an increase in osteopontin ... -
Nanotechnology in medicine – our experiences
Geskovski, Nikola; Mraiche, Fatima; Yalcin, Huseyin C.; Gorachinov, Filip; Moustafa, Diala A.; Dimchevska, Simona; Dodov, Marija Glavas; Crcarevska, Maja Simonoska; Goracinova, Katerina... more authors ... less authors ( Macedonian Pharmaceutical Association , 2022 , Article)The success of design criteria for long-circulating drug delivery systems to support membrane receptor-ligand interaction and internalization has been limited and there is a need to develop smarter approaches for efficient ... -
Nanotechnology – a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer
Gorachinov, Filip; Mraiche, Fatima; Moustafa, Diala Alhaj; Hishari, Ola; Ismail, Yomna; Joseph, Jensa; Crcarevska, Maja Simonoska; Dodov, Marija Glavas; Geskovski, Nikola; Goracinova, Katerina... more authors ... less authors ( Beilstein-Institut Zur Forderung der Chemischen Wissenschaften , 2023 , Article)Genomic and proteomic mutation analysis is the standard of care for selecting candidates for therapies with tyrosine kinase inhibitors against the human epidermal growth factor receptor (EGFR TKI therapies) and further ... -
p90 ribosomal S6 kinase: a potential therapeutic target in lung cancer
Poomakkoth, Noufira; Issa, Aya; Abdulrahman, Nabeel; Abdelaziz, Somaia Gamal; Mraiche, Fatima ( BioMed Central , 2016 , Article)A global survey of cancer has shown that lung cancer is the most common cause of the new cancer cases and cancer deaths in men worldwide. The mortality from lung cancer is more than the combined mortality from breast, ... -
Regulation of Autophagy via Carbohydrate and Lipid Metabolism in Cancer
Alizadeh, Javad; Kavoosi, Mahboubeh; Singh, Navjit; Lorzadeh, Shahrokh; Ravandi, Amir; Kidane, Biniam; Ahmed, Naseer; Mraiche, Fatima; Mowat, Michael R.; Ghavami, Saeid... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)Metabolic changes are an important component of tumor cell progression. Tumor cells adapt to environmental stresses via changes to carbohydrate and lipid metabolism. Autophagy, a physiological process in mammalian cells ... -
Regulation of Autophagy via Carbohydrate and Lipid Metabolism in Cancer
Alizadeh, Javad; Kavoosi, Mahboubeh; Singh, Navjit; Lorzadeh, Shahrokh; Ravandi, Amir; Kidane, Biniam; Ahmed, Naseer; Mraiche, Fatima; Mowat, Michael R.; Ghavami, Saeid... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)Metabolic changes are an important component of tumor cell progression. Tumor cells adapt to environmental stresses via changes to carbohydrate and lipid metabolism. Autophagy, a physiological process in mammalian cells ... -
The role of CD44, hyaluronan and NHE1 in cardiac remodeling.
Suleiman, Muna; Abdurrahman, Nabeel; yalcin, huseyin c; Mraiche, Fatima ( Elsevier , 2018 , Article)Cardiac remodeling, characterized by excessive extracellular matrix (ECM) remodeling, predisposes the heart to failure if left unresolved. Understanding the signaling mechanisms involved in excessive extracellular matrix ... -
The Role of p90 Ribosomal S6 Kinase (RSK) in Tyrosine Kinase Inhibitor (TKI)-Induced Cardiotoxicity
Suleiman, Muna; Al Najjar, Afnan; Zakaria, Zain Z.; Ahmed, Rashid; Yalcin, Huseyin C.; Korashy, Hesham M.; Uddin, Shahab; Riaz, Sadaf; Abdulrahman, Nabeel; Mraiche, Fatima... more authors ... less authors ( Springer , 2023 , Article Review)Targeted therapy, such as tyrosine kinase inhibitors (TKIs), has been approved to manage various cancer types. However, TKI-induced cardiotoxicity is a limiting factor for their use. This issue has raised the need for ... -
THE ROLE OF P90 RIBOSOMAL S6 KINASE AND AUTOPHAGY IN SUNITINIB AND PONATINIB-INDUCED CARDIOTOXICITY
SULEIMAN, MUNA (2019 , Master Thesis)In recent years, the paradigm cancer management has shifted towards a targeted approach. Among the newly targeted anticancer therapies are ponatinib and sunitinib, small molecules tyrosine kinase inhibitors (TKIs), used ... -
Single-Cell RNA Sequencing with Spatial Transcriptomics of Cancer Tissues
Ahmed, Rashid; Zaman, Tariq; Chowdhury, Farhan; Mraiche, Fatima; Tariq, Muhammad; Ahmad, Irfan S.; Hasan, Anwarul... more authors ... less authors ( MDPI , 2022 , Article Review)Single-cell RNA sequencing (RNA-seq) techniques can perform analysis of transcriptome at the single-cell level and possess an unprecedented potential for exploring signatures involved in tumor development and progression. ...