Browsing by Author "Hourani, Shireen"
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EGFR Inhibitor Gefitinib Induces Cardiotoxicity through the Modulation of Cardiac PTEN/Akt/FoxO3a Pathway and Reactive Metabolites Formation: and Rat Studies.
Alhoshani, Ali; Alanazi, Fawaz E; Alotaibi, Moureq R; Attwa, Mohamed W; Kadi, Adnan A; Aldhfyan, Abdullah; Akhtar, Sabah; Hourani, Shireen; Agouni, Abdelali; Zeidan, Asad; Korashy, Hesham M... more authors ... less authors ( American Chemical Society , 2020 , Article)Gefitinib (GEF) is a selective inhibitor of the epidermal growth factor receptor (EGFR) used to treat non-small cell lung cancer. Yet, few cases of cardiotoxicity have been reported. However, the role of the PTEN/Akt/FoxO3a ... -
Epigenetic Regulations of Cancer Stem Cells by the Aryl Hydrocarbon Receptor Pathway
Sabah, Akhtar; Hourani, Shireen; Therachiyil, Lubna; Al-Dhfyan, Abdullah; Agouni, Abdelali; Zeidan, Asad; Uddin, Shahab; Korashy, Hesham M.... more authors ... less authors ( Elsevier , 2020 , Article)Compelling evidence has demonstrated that tumor bulk comprises distinctive subset of cells generally referred as cancer stem cells (CSCs) that has been proposed as a strong sustainer and promoter of tumorigenesis and ...