تصفح حسب المؤلف "n 2011180872"
-
Molecular Profiling of Clear Cell Carcinoma of the Breast Reveals Novel Targetable Biomarkers
Skenderi, Faruk; Palazzo, Juan; Swensen, Jeffrey; Contreras, Elma; Florento, Elena; Gatalica, Zoran; Vranic, Semir... more authors ... less authors ( Springer Nature , 2020 , Conference Paper)Background: Although clear cell morphology may be seen in various subtypes of breast cancer, a pure variant of clear cell carcinoma (usually glycogen-rich) is a very rare primary breast malignancy. It is characterized by ... -
Molecular profiling of the metaplastic spindle cell carcinoma of the breast reveals potentially targetable biomarkers
Semir, Vranic; Stafford, Phillip; Palazzo, Juan; Skenderi, Faruk; Swensen, Jeffrey; Xiu, Joanne; Spetzler, David; Gatalica, Zoran... more authors ... less authors ( Elsevier , 2020 , Article)IntroductionSpindle cell carcinoma is a rare subtype of metaplastic breast cancer (MBC), with triple-negative (TNBC: ER-/PR-/Her2-) phenotype. It is associated with a marked resistance to conventional chemotherapy and has ... -
Novel targetable biomarkers in clear cell carcinoma of the breast uncovered by molecular profiling: A study of nine cases.
Skenderi, Faruk; Palazzo, Juan; Swensen, Jeffrey; Feldman, Rebecca; Contreras, Elma; Florento, Elena; Gatalica, Zoran; Vranic, Semir... more authors ... less authors ( Wiley , 2020 , Article)We profiled nine pure clear cell carcinomas of the breast using massively parallel DNA and RNA sequencing (NGS), in situ hybridization (ISH), and immunohistochemistry (IHC). All cases were primary mammary clear cell ... -
PD-L1 status in breast cancer: Current view and perspectives.
Vranic, Semir; Cyprian, Farhan S; Gatalica, Zoran; Palazzo, Juan ( Elsevier , 2019 , Article)Breast cancer was traditionally not considered a particularly immunogenic tumor. However, recent developments have shown that some aggressive triple-negative breast cancers are immunogenic, exhibit a resistance to chemotherapy ... -
Potential Novel Therapy Targets in Neuroendocrine Carcinomas of the Breast.
Vranic, Semir; Palazzo, Juan; Sanati, Souzan; Florento, Elena; Contreras, Elma; Xiu, Joanne; Swensen, Jeffrey; Gatalica, Zoran... more authors ... less authors ( Elsevier , 2018 , Article)Neuroendocrine carcinoma (NEC) of the breast is a rare, special type of breast cancer, reportedly constituting 2% to 5% of all breast cancers. Although breast NEC does not have a specific targeted therapy, several new ... -
Theranostic molecular profiling of pleomorphic ductal carcinoma of the breast.
Vranic, Semir; Palazzo, Juan; Swensen, Jeffrey; Xiu, Joanne; Florento, Elena; Gatalica, Zoran... more authors ... less authors ( Wiley , 2019 , Other)Pleomorphic ductal carcinoma (PDC) is a very rare subtype of invasive ductal carcinoma of no‐special type (NST), characterized by the presence of highly atypical/bizarre (>6‐fold variation in nuclear size) and multinucleated ...