Browsing by Author "Steinhoff, Martin"
Now showing items 1-11 of 11
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Epigenetic programing of cancer stemness by transcription factors-non-coding RNAs interactions
Alsayed, Reem Khaled M.E.; Sheikhan, Khalid Sultan A.M.; Alam, Majid Ali; Buddenkotte, Jorg; Steinhoff, Martin; Uddin, Shahab; Ahmad, Aamir... more authors ... less authors ( Elsevier , 2023 , Article Review)Cancer ‘stemness’ is fundamental to cancer existence. It defines the ability of cancer cells to indefinitely perpetuate as well as differentiate. Cancer stem cell populations within a growing tumor also help evade the ... -
Epigenetic regulation of CXCR4 signaling in cancer pathogenesis and progression
Reem Khaled M.E., Alsayed; Khan, Abdul Q.; Ahmad, Fareed; Ansari, Abdul Wahid; Alam, Majid Ali; Buddenkotte, Jorg; Steinhoff, Martin; Uddin, Shahab; Ahmad, Aamir... more authors ... less authors ( Elsevier , 2022 , Article)Signaling involving chemokine receptor CXCR4 and its ligand SDF-1/CXL12 has been investigated for many years for its possible role in cancer progression and pathogenesis. Evidence emerging from clinical studies in recent ... -
F-box proteins in cancer stemness: An emerging prognostic and therapeutic target
Abdul Q., Khan; Al-Tamimi, Maha; Uddin, Shahab; Steinhoff, Martin ( Elsevier , 2021 , Article)Cancer is a complex heterogenic disease with significant therapeutic challenges. The presence of cancer stem cells (CSCs) in cancer tissue orchestrates tumor growth, progression, and metastasis, the tumor heterogeneity, ... -
Fc Epsilon RI–Neuroimmune Interplay in Pruritus Triggered by Particulate Matter in Atopic Dermatitis Patients
Isaifan, Dina; Crovella, Sergio; Soubra, Lama; Al-Nesf, Maryam; Steinhoff, Martin ( MDPI , 2023 , Article Review)Atopic dermatitis (AD) is the most common chronic relapsing neuroinflammatory skin disease that is characterized by a complex and multifactorial pathophysiology. It reflects a profound interplay between genetic and ... -
House dust mite-treated PAR2 over-expressor mouse: A novel model of atopic dermatitis
Smith, Leila; Gatault, Solene; Casals-Diaz, Laura; Kelly, Pamela A.; Camerer, Eric; Métais, Charles; Knaus, Ulla G.; Eissner, Günther; Steinhoff, Martin... more authors ... less authors ( Blackwell Publishing Ltd , 2019 , Article)Background Atopic dermatitis (AD) is a complex skin disease involving causative effects from both intrinsic and extrinsic sources. Murine models of the disease often fall short in one of these components and, as a result, ... -
Molecular pathogenesis of Cutaneous T cell Lymphoma: Role of chemokines, cytokines, and dysregulated signaling pathways
Kalyani, Patil; Kuttikrishnan, Shilpa; Khan, Abdul Q.; Ahmad, Fareed; Alam, Majid; Buddenkotte, Joerg; Ahmad, Aamir; Steinhoff, Martin; Uddin, Shahab... more authors ... less authors ( Elsevier , 2022 , Article Review)Cutaneous T cell lymphomas (CTCLs) are a heterogeneous group of lymphoproliferative neoplasms that exhibit a wide spectrum of immune-phenotypical, clinical, and histopathological features. The biology of CTCL is complex ... -
The Role of Extracellular Vesicles as Modulators of the Tumor Microenvironment, Metastasis and Drug Resistance in Colorectal Cancer.
Siveen, Kodappully S; Raza, Afsheen; Ahmed, Eiman I; Khan, Abdul Q; Prabhu, Kirti S; Kuttikrishnan, Shilpa; Mateo, Jericha M; Zayed, Hatem; Rasul, Kakil; Azizi, Fouad; Dermime, Said; Steinhoff, Martin; Uddin, Shahab... more authors ... less authors ( MDPI , 2019 , Article)Colorectal cancer (CRC) is one of the most common cancers worldwide, with high morbidity and mortality rates. A number of factors including modulation of the tumor microenvironment, high metastatic capability, and resistance ... -
Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling.
Akhtar, Sabah; Achkar, Iman W; Siveen, Kodappully S; Kuttikrishnan, Shilpa; Prabhu, Kirti S; Khan, Abdul Q; Ahmed, Eiman I; Sahir, Fairooz; Jerobin, Jayakumar; Raza, Afsheen; Merhi, Maysaloun; Elsabah, Hesham M; Taha, Ruba; Omri, Halima El; Zayed, Hatem; Dermime, Said; Steinhoff, Martin; Uddin, Shahab... more authors ... less authors ( Frontiers Media , 2019 , Article)Sanguinarine (SNG), a benzophenanthridine alkaloid, has displayed various anticancer abilities in several vivo and studies. However, the anticancer potential of SNG is yet to be established in multiple myeloma (MM), a ... -
Sanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway
Kirti.S., Prabhu; Bhat, Ajaz A.; Siveen, Kodappully S.; Kuttikrishnan, Shilpa; Raza, Syed Shadab; Raheed, Thesni; Jochebeth, Anh; Khan, Abdul Q.; Chawdhery, M.Zafar; Haris, Mohammad; Kulinski, Michal; Dermime, Said; Steinhoff, Martin; Uddin, Shahab... more authors ... less authors ( Elsevier , 2021 , Article)Effective treatment of lung cancer remains a significant clinical challenge due to its multidrug resistance and side effects of the current treatment options. The high mortality associated with this malignancy indicates ... -
Synergistic antipruritic effects of gamma aminobutyric acid A and B agonists in a mouse model of atopic dermatitis
Cevikbas, Ferda; Braz, Joao M.; Wang, Xidao; Solorzano, Carlos; Sulk, Mathias; Buhl, Timo; Steinhoff, Martin; Basbaum, Allan I.... more authors ... less authors ( Mosby Inc. , 2017 , Article)Background Despite recent insights into the pathophysiology of acute and chronic itch, chronic itch remains an often intractable condition. Among major contributors to chronic itch is dysfunction of spinal cord gamma ... -
The effect of migration on the incidence of new-onset metabolic syndrome in migrants to Qatar
AlAdawi, Rana Moustafa; Prabhu, Kirti S.; Stewart, Derek; Rayan, Cristin; Abdelaziz, Hani; EL Edrisi, Mohsen; Izham, Mohamed; Jochebeth, Anh; Kuttikrishnan, Shilpa; Young, Monica; Steinhoff, Martin; Uddin, Shahab; Tonna, Antonella... more authors ... less authors ( Hamad bin Khalifa University Press (HBKU Press) , 2022 , Article)Background: There is substantial evidence that migration to Western countries is associated with an increased risk of metabolic syndrome (MetS) 1 . However, there is a paucity of data on the incidence of MetS in migrants ...