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المؤلفVaradharajan, Kavitha
المؤلفShanmugakonar, Muralitharan
المؤلفDas, Sandra Concepcion
المؤلفAl-Naemi, Hamda A.
تاريخ الإتاحة2019-04-16T10:37:36Z
تاريخ النشر2018
اسم المنشورAdvances in Microbiology
المعرّفhttp://dx.doi.org/10.4236/aim.2018.812066
الاقتباسVaradharajan, K., Shanmugakonar, M., Das, S.C. and Al-Naemi, H.A. (2018) Gut Microbiota Dysbiosis in Cafeteria Diet Fed Sprague Dawley Rats. Advances in Microbiology, 8, 975-993. https://doi.org/10.4236/aim.2018.812066
الرقم المعياري الدولي للكتاب2165-3402
معرّف المصادر الموحدhttp://hdl.handle.net/10576/11485
الملخصDiet plays a major role in the body physiology and metabolism. The quantity, nature and stability of the macronutrients present in the diet have a major impact on the composition of gut microbiota. Gut microbiota plays a major role in the body metabolism and leads to obese or lean phenotype. Bacteriodetes, Firmicutes, Proteobacteria and Actinobacteria are the major microbes that inhabit in the region of the gut. We made an attempt to study the effects of Cafeteria (CAF) diets and normal chow diets on diet consumption, weight gain, metabolism and composition of gut microbiota in fecal and cecum samples from three weeks old Sprague Dawley (SD) rats (n = 18/group) using 16S rDNA high throughput sequencing. Results revealed that distinctive diet based phenotypical changes were observed in some of the Cafeteria diet fed rats. Interestingly, some weight gain resistant (WGR) animals in Cafeteria diet fed groups show similar trend like that of control normal chow fed rats. Fecal microbiome analysis indicates that the ratio of Bacteriodetes is higher than the Firmicutes in cecum samples of Cafeteria diet fed rats whereas no significant difference is found in fecal samples of Cafeteria diet fed rats and as well as in control rats. Further analysis of other taxa at the level of family and genus of microbial abundance are also discussed. Our study suggests that contribution of gut microbiota towards obesity is not at the phylum level, and microbiome composition even at the level of species or strain may exert impact on the metabolism of the Cafeteria diet.
اللغةen
الناشرScientific Research Publishing
الموضوعGut Microbiota
Obesity
Cafeteria Diet
Feces
Weight Gain Resistant
Next Generation Sequencing
العنوانGut Microbiota Dysbiosis in Cafeteria Diet Fed Sprague Dawley Rats
النوعArticle
الصفحات975-993
رقم العدد12
رقم المجلد8
ESSN2165-3410


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