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المؤلفAl-Khelaifi, Fatima
المؤلفDiboun, Ilhame
المؤلفDonati, Francesco
المؤلفBotre, Francesco
المؤلفAbraham, David
المؤلفHingorani, Aroon
المؤلفAlbagha, Omar
المؤلفGeorgakopoulos, Costas
المؤلفSuhre, Karsten
المؤلفYousri, Noha A
تاريخ الإتاحة2020-01-14T05:07:51Z
تاريخ النشر2019-12-01
اسم المنشورScientific Reports
المعرّفhttp://dx.doi.org/10.1038/s41598-019-56496-7
الاقتباسAl-Khelaifi, F., Diboun, I., Donati, F. et al. Metabolic GWAS of elite athletes reveals novel genetically-influenced metabolites associated with athletic performance. Sci Rep 9, 19889 (2019) doi:10.1038/s41598-019-56496-7
معرّف المصادر الموحدhttp://hdl.handle.net/10576/12535
الملخصGenetic research of elite athletic performance has been hindered by the complex phenotype and the relatively small effect size of the identified genetic variants. The aims of this study were to identify genetic predisposition to elite athletic performance by investigating genetically-influenced metabolites that discriminate elite athletes from non-elite athletes and to identify those associated with endurance sports. By conducting a genome wide association study with high-resolution metabolomics profiling in 490 elite athletes, common variant metabolic quantitative trait loci (mQTLs) were identified and compared with previously identified mQTLs in non-elite athletes. Among the identified mQTLs, those associated with endurance metabolites were determined. Two novel genetic loci in FOLH1 and VNN1 are reported in association with N-acetyl-aspartyl-glutamate and Linoleoyl ethanolamide, respectively. When focusing on endurance metabolites, one novel mQTL linking androstenediol (3alpha, 17alpha) monosulfate and SULT2A1 was identified. Potential interactions between the novel identified mQTLs and exercise are highlighted. This is the first report of common variant mQTLs linked to elite athletic performance and endurance sports with potential applications in biomarker discovery in elite athletic candidates, non-conventional anti-doping analytical approaches and therapeutic strategies.
راعي المشروع“This study was funded by Qatar National Research Fund (QNRF), Grant number NPRP7-272-1-041 (MAE, KS, CG and FB). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.” should read: “This study was funded by Qatar National Research Fund (QNRF), Grant number NPRP7-272-1-041 (MAE, KS, CG and FB). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The publication of this article was funded by the Qatar National Library.”
اللغةen
الناشرNature Research
الموضوعmGWAS, elite athletes
العنوانMetabolic GWAS of elite athletes reveals novel genetically-influenced metabolites associated with athletic performance.
النوعArticle
رقم العدد1
رقم المجلد9
ESSN2045-2322


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