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المؤلفXu, Chang
المؤلفZhou, Xiaoqin
المؤلفZorzela, Liliane
المؤلفJu, Ke
المؤلفFuruya-Kanamori, Luis
المؤلفLin, Lifeng
المؤلفLu, Cuncun
المؤلفMusa, Omran A H
المؤلفVohra, Sunita
تاريخ الإتاحة2021-06-22T11:14:30Z
تاريخ النشر2021-06-15
اسم المنشورBMC Medicine
المعرّفhttp://dx.doi.org/10.1186/s12916-021-02008-2
الاقتباسXu, C., Zhou, X., Zorzela, L. et al. Utilization of the evidence from studies with no events in meta-analyses of adverse events: an empirical investigation. BMC Med 19, 141 (2021). https://doi.org/10.1186/s12916-021-02008-2
الرقم المعياري الدولي للكتاب1741-7015
المعرّفArticle number: 141
معرّف المصادر الموحدhttp://hdl.handle.net/10576/20822
الملخصZero-events studies frequently occur in systematic reviews of adverse events, which consist of an important source of evidence. We aimed to examine how evidence of zero-events studies was utilized in the meta-analyses of systematic reviews of adverse events. We conducted a survey of systematic reviews published in two periods: January 1, 2015, to January 1, 2020, and January 1, 2008, to April 25, 2011. Databases were searched for systematic reviews that conducted at least one meta-analysis of any healthcare intervention and used adverse events as the exclusive outcome. An adverse event was defined as any untoward medical occurrence in a patient or subject in healthcare practice. We summarized the frequency of occurrence of zero-events studies in eligible systematic reviews and how these studies were dealt with in the meta-analyses of these systematic reviews. We included 640 eligible systematic reviews. There were 406 (63.45%) systematic reviews involving zero-events studies in their meta-analyses, among which 389 (95.11%) involved single-arm-zero-events studies and 223 (54.93%) involved double-arm-zero-events studies. The majority (98.71%) of these systematic reviews incorporated single-arm-zero-events studies into the meta-analyses. On the other hand, the majority (76.23%) of them excluded double-arm-zero-events studies from the meta-analyses, of which the majority (87.06%) did not discuss the potential impact of excluding such studies. Systematic reviews published at present (2015-2020) tended to incorporate zero-events studies in meta-analyses than those published in the past (2008-2011), but the difference was not significant (proportion difference=-0.09, 95% CI -0.21 to 0.03, p = 0.12). Systematic review authors routinely treated studies with zero-events in both arms as "non-informative" carriers and excluded them from their reviews. Whether studies with no events are "informative" or not largely depends on the methods and assumptions applied, thus sensitivity analyses using different methods should be considered in future meta-analyses
راعي المشروعQatar National Library
اللغةen
الناشرSpringer
الموضوعAdverse events
Meta-analysis
Systematic review
Zero-events studies
العنوانUtilization of the evidence from studies with no events in meta-analyses of adverse events: an empirical investigation
النوعArticle
رقم المجلد19


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