عرض بسيط للتسجيلة

Targeting dopaminergic system for treating nicotine dependence

المؤلفAbuhamdah, Sawsan
المؤلفKhalil, Ashraf
المؤلفSari, Youssef
تاريخ الإتاحة2021-09-01T10:02:40Z
تاريخ النشر2016
اسم المنشورCentral Nervous System Agents in Medicinal Chemistry
المصدرScopus
معرّف المصادر الموحدhttp://dx.doi.org/10.2174/1871524916666151104115421
معرّف المصادر الموحدhttp://hdl.handle.net/10576/22346
الملخصBackground: Smoking is the world's leading cause of preventable death among populations. Cigarette smoking increases the risk of numerous health problems, including heart diseases, stroke, atherosclerosis and many types of cancer, including lung, stomach and bladder cancers. Outcomes: Many individuals find it difficult to stop smoking because of the addictive effects of nicotine and the presence of several monoamine oxidase (MAO) inhibitors in the tobacco smoke extract. Objective: The development of novel, safe and effective medications for smoking cessation is a high public health priority. Results: The role of mesocorticolimbic dopaminergic pathways in withdrawal symptoms and general reinforcement processes clearly recommends dopaminergic system as a potential target for the treatment of nicotine addiction. Conclusion: This review article discusses the new pharmacological treatments of nicotine dependence, which are targeting dopaminergic neurotransmission. This includes blockade of dopamine transporter and inhibition of MAO as pharmacotherapy for the treatment of nicotine dependence. 2016 Bentham Science Publishers.
اللغةen
الناشرBentham Science Publishers B.V.
الموضوع2 naphthylamine
amfebutamone
beta carboline
dopamine
dopamine receptor
dopamine transporter
farnesol
gsk 598809
harman
monoamine oxidase A inhibitor
monoamine oxidase B inhibitor
monoamine oxidase inhibitor
n [4 [2 (6 cyano 1,2,3,4 tetrahydro 2 isoquinolinyl)ethyl]cyclohexyl] 4 quinolinecarboxamide
nicotine
noradrenalin
presynaptic receptor
serotonin
dopamine
dopamine receptor blocking agent
dopamine transporter
monoamine oxidase inhibitor
Article
dopamine release
dopamine uptake
dopaminergic nerve cell
dopaminergic system
drug dependence
drug targeting
GABAergic system
glutamatergic synapse
human
microdialysis
neurotransmission
nicotine replacement therapy
positron emission tomography
prefrontal cortex
public health
risk factor
smoking cessation
smoking habit
tobacco
tobacco dependence
ventral tegmentum
withdrawal syndrome
animal
antagonists and inhibitors
drug delivery system
metabolism
procedures
Tobacco Use Disorder
treatment outcome
Animals
Dopamine
Dopamine Antagonists
Dopamine Plasma Membrane Transport Proteins
Drug Delivery Systems
Humans
Monoamine Oxidase Inhibitors
Smoking Cessation
Tobacco Use Disorder
Treatment Outcome
العنوانTargeting dopaminergic system for treating nicotine dependence
النوعArticle
الصفحات137-142
رقم العدد2
رقم المجلد16


الملفات في هذه التسجيلة

الملفاتالحجمالصيغةالعرض

لا توجد ملفات لها صلة بهذه التسجيلة.

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة